An association study of D-amino acid oxidase and D-amino acid oxidase activator polymorphisms and schizophrenia in patients from Turkey

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dc.authoridAkın Sarı, Burcu/0000-0002-9730-7206
dc.authoridAcar, Ceren/0000-0003-1842-9203
dc.authoridkartalcı, şükrü/0000-0003-2560-0355;
dc.authorwosidAkın Sarı, Burcu/S-3910-2019
dc.authorwosidAcar, Ceren/M-2926-2019
dc.authorwosidkartalcı, şükrü/ABI-1106-2020
dc.authorwosidAcar, Ceren/B-5758-2008
dc.contributor.authorKartalci, Sukru
dc.contributor.authorAcar, Ceren
dc.date.accessioned2024-08-04T20:10:26Z
dc.date.available2024-08-04T20:10:26Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Schizophrenia is a highly heritable complex disease. The genetic interactions underlying this heritability is still needs to be understood. Linkage studies pointed out the D-amino acid oxidase (DAO) and D-amino acid oxidase activator (DAOA-G72) genes as candidate genes in susceptibility to schizophrenia. The association studies of interaction partners D-amino acid oxidase and D-amino acid oxidase activator gene polymorphisms and schizophrenia has been performed in different studies with different ethnic origins. However these studies showed conflicting results. In this study, it is aimed to examine the effects of several DAO and DAOA polymorphisms in Turkish schizophrenia patients. Methods: In the present study two single nucleotide polymorphisms (SNPs) within DAO gene (rs2111902 and rs3741775) and one in DAOA gene (rs2391191) were genotyped in individuals with Turkish origin from Malatya region on eastern part of Turkey. 96 schizophrenia patients and 100 mentally healthy individuals are the subjects of this study. Results: No significant difference was found in between the controls and schizophrenia sample for the SNPs rs2111902 and rs3741775 of DAO gene but a significant association was found on the allelic level of rs2391191 of DAOA gene. The relationship between aggressive behaviour, suicide attempts and genotypes were also evaluated in the patient group. Discussion: A significant association for the G allele of rs2391191 at the allelic level (p=0.036) was found, on the other hand no association could be shown between the examined rs2111902 and rs3741775 polymorphisms and the pathology of the disorder in the group of Turkish schizophrenia patients included in this study.en_US
dc.identifier.doi10.5455/apd.176178
dc.identifier.endpage346en_US
dc.identifier.issn1302-6631
dc.identifier.issue5en_US
dc.identifier.startpage341en_US
dc.identifier.trdizinid203800en_US
dc.identifier.urihttps://doi.org/10.5455/apd.176178
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/203800
dc.identifier.urihttps://hdl.handle.net/11616/92787
dc.identifier.volume17en_US
dc.identifier.wosWOS:000388116800003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherCumhuriyet Univ Tip Fak Psikiyatri Anabilim Dalien_US
dc.relation.ispartofAnadolu Psikiyatri Dergisi-Anatolian Journal of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDAOen_US
dc.subjectDAOAen_US
dc.subjectG72en_US
dc.subjectschizophreniaen_US
dc.subjectTurkish populationen_US
dc.subjectSNPen_US
dc.subjectgeneticsen_US
dc.titleAn association study of D-amino acid oxidase and D-amino acid oxidase activator polymorphisms and schizophrenia in patients from Turkeyen_US
dc.typeArticleen_US

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