The protective role of molsidomine on the cisplatin Induced ototoxicity

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dc.contributor.authorToplu, Yüksel
dc.contributor.authorParlakpınar, Hakan
dc.contributor.authorSapmaz, Emrah
dc.contributor.authorKarataş, Erkan
dc.contributor.authorPolat, Alaattin
dc.contributor.authorKızılay, Ahmet
dc.date.accessioned2017-05-29T13:59:01Z
dc.date.available2017-05-29T13:59:01Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis experimental study was designed to investigate the protective effects of molsidomine (MOL) on against cisplatin-induced ototoxicity (CIO). To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status [including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPX), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI)] were evaluated. Thirty-two female wistar albino rats were divided into four groups including; control (Group K), cisplatin (Group C), cisplatin plus MOL group (Group CM), and MOL group (Group M). DPOAEs measurements between 0.9961 and 8.0003 Hz as DP-gram and input/output (I/O) functions were performed in the same (left) ear of all rats on days 0, 1st, 5th and 12th. Prior to death, the last DPOAEs measurements and blood samples were taken. In the C group, statistically significant DPOAE amplitude reductions were detected at 2.5195, 3.1758, 3.9961, 5.0391, 6.3516 and 8.0039 Hz frequencies (p\0.05) between 0th and 1st, 0th and 5th and 0th and 12th days’ measurements (p\0.05). Serum level of MDA, TAC and OSI levels were significantly higher in the C group versus K group (p\0.05). In the CM group, there were no significant differences at all frequencies between 0th and other days’ measurements (p[0.05) and the serum levels of all biochemical parameters were shifted toward normal values, similar to the K group (p\0.05). No significant differences were detected in the either M or K group’s measurements. According to these results, cisplatin-related ototoxicity has been significantly prevented by MOL.en_US
dc.identifier.citationToplu, Y. Parlakpınar, H. Sapmaz, E. Karataş, E. Polat, A. Kızılay, A. (2014). The Protective Role of Molsidomine on the Cisplatin Induced Ototoxicity. Indian Journal of Otolaryngology and Head & Neck Surgery, 66(3), 314–319.en_US
dc.identifier.doi10.1007/s12070-014-0718-2en_US
dc.identifier.endpage319en_US
dc.identifier.issn2231-3796
dc.identifier.issue3en_US
dc.identifier.startpage314en_US
dc.identifier.urihttp://link.springer.com/10.1007/s12070-014-0718-2
dc.identifier.urihttps://hdl.handle.net/11616/6993
dc.identifier.volume66en_US
dc.language.isoenen_US
dc.publisherIndian Journal of Otolaryngology and Head & Neck Surgeryen_US
dc.relation.ispartofIndian Journal of Otolaryngology and Head & Neck Surgeryen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCisplatinen_US
dc.subjectMolsidomineen_US
dc.subjectOtoacoustic emissionsen_US
dc.subjectOxidative statusen_US
dc.subjectOtotoxicityen_US
dc.titleThe protective role of molsidomine on the cisplatin Induced ototoxicityen_US
dc.typeArticleen_US

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