Is there a clinical correlate to the histological and radiological evidence of inflammation in trans-ligamentous extruded and sequestered lumbar disc herniaton?

Basit Öğe Kaydı
dc.contributor.authorÇayli, SR
dc.contributor.authorKoçak, A
dc.contributor.authorAlkan, A
dc.contributor.authorKirimlioglu, H
dc.date.accessioned2024-08-04T20:13:41Z
dc.date.available2024-08-04T20:13:41Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe pain of lumbar disc herniation is related to direct compression of the nerve root and to the foreign-body inflammatory response to the herniated disc material. In this study, we attempted to identify disc-related inflammation in trans-ligamentous extruded and sequestered lumbar disc herniation using gadolinium-DPTA-enhanced T1-weighted and short-time inversion recovery ( STIR) magnetic resonance imaging. We assessed how these results related to each other, and to patients' clinical status, and to immunohistochemistry findings in disc specimens removed at surgery. Forty-one patients with transligamentous extruded or sequestered disc herniation were investigated clinically and radiologically. Twenty-five patients who did not respond to initial medical treatment or who had progressive neurological deficits underwent discectomy. Specimens of disc material removed during surgery were studied immunohistochemically and inflammatory cell types were identified. The other 16 patients showed good response to treatment, and were given further medical therapy and monitored for a mean of 6.3 months of follow-up. All radiological diagnoses in the operated cases were confirmed at surgery. There were no significant differences among the rates of detection of inflammation by contrast MRI, STIR technique, and immunohistochemistry in the surgical treated cases. In the medically treated cases, the frequency of radiological evidence of inflammation on the initial contrast enhanced T1-weighted and STIR images was similar to the frequency observed on the most recent scans done during follow-up. The study showed that the radiological and immunohistochemical evidence of inflammation in these cases does not correspond with patients' clinical pain profiles over time. It also revealed that STIR and contrast T1W are equally reliable for detecting inflammation in trans-ligamentous extruded or sequestered lumbar disc herniation. In future, studies that focus on physical and chemical mechanisms of pain in lumbar disc herniation in larger series of conservatively and surgically treated patients may clarify the link between inflammation and radicular pain in these types of disc herniation.en_US
dc.identifier.doi10.1080/02688690400022862
dc.identifier.endpage583en_US
dc.identifier.issn0268-8697
dc.identifier.issn1360-046X
dc.identifier.issue6en_US
dc.identifier.pmid15799188en_US
dc.identifier.scopus2-s2.0-11944270358en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage576en_US
dc.identifier.urihttps://doi.org/10.1080/02688690400022862
dc.identifier.urihttps://hdl.handle.net/11616/93782
dc.identifier.volume18en_US
dc.identifier.wosWOS:000225876300002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBritish Journal of Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdisc herniationen_US
dc.subjectimmunohistochemistryen_US
dc.subjectinflammationen_US
dc.subjectlumbaren_US
dc.subjectmagnetic resonance imagingen_US
dc.subjectSTIRen_US
dc.titleIs there a clinical correlate to the histological and radiological evidence of inflammation in trans-ligamentous extruded and sequestered lumbar disc herniaton?en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu