Therapeutic drug monitoring of vancomycin in the case of augmented renal clearance: a case report of a paediatric patient

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dc.authoridMemiş, Hasan/0000-0001-7158-1795
dc.authoridÇakır, Ahmet/0000-0002-9843-1604
dc.authorwosidMemiş, Hasan/AAA-9596-2022
dc.authorwosidÇakır, Ahmet/ABH-5565-2020
dc.contributor.authorMemis, Hasan
dc.contributor.authorCakir, Ahmet
dc.contributor.authorUlgey, Ayse
dc.date.accessioned2024-08-04T20:55:01Z
dc.date.available2024-08-04T20:55:01Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAugmented renal clearance (ARC) is a condition in which renal circulation increases, causing drug levels in the blood to remain at subtherapeutic levels in severe trauma patients. Vancomycin, a hydrophilic anti-Gram-positive drug, has been shown in the literature to have its levels fall below the therapeutic range in the case of ARC. However, vancomycin dosing recommendations in the case of ARC are still lacking. Here, we identify an ARC case measured with urinary creatinine clearance in a severe trauma paediatric patient, causing vancomycin blood trough levels to drop. We could not be able to increase the vancomycin trough levels with intermittent dosing; hence, we administered vancomycin with continuous infusion, and this resulted in vancomycin blood trough levels remaining in the therapeutic range. No adverse effect was seen. Continuous infusion of vancomycin can be safely administered to paediatric patients in these cases.en_US
dc.identifier.doi10.1136/ejhpharm-2023-003982
dc.identifier.issn2047-9956
dc.identifier.issn2047-9964
dc.identifier.pmid38199810en_US
dc.identifier.scopus2-s2.0-85183838279en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1136/ejhpharm-2023-003982
dc.identifier.urihttps://hdl.handle.net/11616/101790
dc.identifier.wosWOS:001142642400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmj Publishing Groupen_US
dc.relation.ispartofEuropean Journal of Hospital Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPHARMACY SERVICE, HOSPITALen_US
dc.subjectDrug Monitoringen_US
dc.subjectCritical Careen_US
dc.subjectCase Reportsen_US
dc.subjectPEDIATRICSen_US
dc.titleTherapeutic drug monitoring of vancomycin in the case of augmented renal clearance: a case report of a paediatric patienten_US
dc.typeArticleen_US

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