Peripheral Blood Smear Findings of COVID-19 Patients Provide Information about the Severity of the Disease and the Duration of Hospital Stay

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dc.authoridSARICI, Ahmet/0000-0002-5916-0119
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridulutas, ozkan/0000-0002-2155-8340
dc.authorwosidSARICI, Ahmet/ABI-7512-2020
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidulutas, ozkan/ABI-6332-2020
dc.contributor.authorBerber, Ilhami
dc.contributor.authorCagasar, Ozlem
dc.contributor.authorSarici, Ahmet
dc.contributor.authorBerber, Nurcan Kirici
dc.contributor.authorAydogdu, Ismet
dc.contributor.authorUlutas, Ozkan
dc.contributor.authorYildirim, Asli
dc.date.accessioned2024-08-04T20:49:14Z
dc.date.available2024-08-04T20:49:14Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Data about the morphological changes in peripheral blood smears during COVID-19 infection and their clinical severity association are limited. We aimed to examine the characteristics of the cells detected in the pathological rate and/or appearance and whether these findings are related to the clinical course by evaluating the peripheral blood smear at the time of diagnosis in COVID-19 patients. Methods: Clinical features, laboratory data, peripheral blood smear of fifty patients diagnosed with COVID-19 by PCR was evaluated at diagnosis. Peripheral smear samples of the patients were compared with the age and sex-matched 30 healthy controls. Pictures were taken from the patient's peripheral blood smear. Patients were divided into two groups. Mild and severe stage patient groups were compared in terms of laboratory data and peripheral smear findings. The relationship between the laboratory values of all patients and the duration of hospitalization was analyzed. Results: The number of segmented neutrophils and eosinophils were low, pseudo-Pelger-Huet, pseudo-Pelger-Huet/mature lymphocyte ratio, atypical lymphocytes, monocytes with vacuoles, bands, and pyknotic neutrophils rates were higher in the peripheral blood smear of the patient group (p<0.05). Increased pseudo-Pelger-Huet anomaly, pseudo-Pelger Huet/mature lymphocyte ratio, a decreased number of mature lymphocytes, and eosinophils in peripheral blood smear were observed in the severe stage patients (p<0.05). A negative correlation was observed between hospitalization duration and mature lymphocyte and monocytes with vacuoles rates (p<0.05). Conclusion: A peripheral blood smear is an inexpensive, easily performed, and rapid test. Increased Pseudo-Pelger-Huet anomaly/mature lymphocyte rate suggests a severe stage disease, while high initial mature lymphocyte and monocytes with vacuoles rates at the time of diagnosis may be an indicator of shortened duration of hospitalization.en_US
dc.identifier.doi10.4084/MJHID.2021.009
dc.identifier.issn2035-3006
dc.identifier.pmid33489048en_US
dc.identifier.scopus2-s2.0-85099619718en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.4084/MJHID.2021.009
dc.identifier.urihttps://hdl.handle.net/11616/99719
dc.identifier.volume13en_US
dc.identifier.wosWOS:000608407400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMattioli 1885en_US
dc.relation.ispartofMediterranean Journal of Hematology and Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPseudo-Pelger Huet anomalyen_US
dc.subjectMature lymphocytesen_US
dc.subjectMonocytes with vacuolesen_US
dc.subjectSevere COVID-19en_US
dc.titlePeripheral Blood Smear Findings of COVID-19 Patients Provide Information about the Severity of the Disease and the Duration of Hospital Stayen_US
dc.typeArticleen_US

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