Synthesis, In Vitro Biological Evaluation, and Molecular Docking Studies of Novel Biphenyl Chalcone Derivatives as Antimicrobial Agents

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dc.authoridalagoz, mehmet abdullah/0000-0001-5190-7196
dc.authorwosidalagoz, mehmet abdullah/W-7847-2018
dc.contributor.authorBurmaoglu, Serdar
dc.contributor.authorKazancioglu, Elif Akin
dc.contributor.authorKazancioglu, Mustafa Z.
dc.contributor.authorAlagoz, Mehmet Abdullah
dc.contributor.authorDogen, Aylin
dc.contributor.authorAlgul, Oztekin
dc.date.accessioned2024-08-04T20:50:32Z
dc.date.available2024-08-04T20:50:32Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe increasing resistance to antimicrobial drugs has instigated the crucial need for the discovery of novel compounds with different modes of action that could target both sensitive and resistant strains. For this purpose, we developed some new chalcone analogs. Herein, a novel series of hybrid biphenyl chalcones (17-24), which have organohalogens in their B ring, were synthesized and examined for their antimicrobial effect. The position of the substituent on ring B was changed to find the effect of the substitution on antimicrobial activity. Compounds 18, 19, and 24 showed better antibacterial and antifungal activity when compared other compounds. Also, molecular docking studies on ATP binding site of S. aureus DNA gyrase for antibacterial targets were performed to elucidate the mechanism of antibacterial activity of synthesized compounds. Three of the most active compounds could be considered as lead compounds for the development of more new potent agents.en_US
dc.identifier.doi10.1080/10406638.2021.1962925
dc.identifier.endpage5961en_US
dc.identifier.issn1040-6638
dc.identifier.issn1563-5333
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-85112027038en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage5948en_US
dc.identifier.urihttps://doi.org/10.1080/10406638.2021.1962925
dc.identifier.urihttps://hdl.handle.net/11616/100106
dc.identifier.volume42en_US
dc.identifier.wosWOS:000683182000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPolycyclic Aromatic Compoundsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobial activityen_US
dc.subjectbiphenyl chalconeen_US
dc.subjectMICen_US
dc.subjectmolecular dockingen_US
dc.subjectsynthesisen_US
dc.titleSynthesis, In Vitro Biological Evaluation, and Molecular Docking Studies of Novel Biphenyl Chalcone Derivatives as Antimicrobial Agentsen_US
dc.typeArticleen_US

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