The effects of different fluid resuscitations in the acute phase of combined traumatic brain injury and hemorrhagic shock in an experimental rat model

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dc.contributor.authorPepele, Mustafa Safa
dc.contributor.authorYücel, Neslihan
dc.contributor.authorÖztanır, Mustafa Namık
dc.contributor.authorKaradağ, Neşe
dc.contributor.authorTakmaz, Ali Alper
dc.contributor.authorOzyalin, Fatma
dc.date.accessioned2024-08-04T19:53:17Z
dc.date.available2024-08-04T19:53:17Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIt was aimed to investigate the utility of different fluid replacement therapies in the acute phase of a combined experimental traumatic brain injury and hemorrhagic shock model in terms of biochemical, hemostatic and pathological changes in the brain. 48 rats were divided up into 6 groups (n=8). Control group (S) rats were subjected to sham experimental hemorrhagic shock after which they underwent a sham operation, while trauma group (T) rats were subjected to hemorrhagic shock and subsequent head trauma with no treatment. Among the rats subjected to hemorrhagic shock and subsequent head trauma, those given 3% NaCl after this were named as HS group; those given HyperHeas [7.2% NaCl / 6% poly (O-2-Hydroxyethyl) starch] were named as HyperHS group; those given 0.9% NaCl were determined as NS group and those given ringer lactate as RL group. 24-hours later, the fluids’ effects were evaluated. The brain fluid content and INR levels were significantly higher in all the experimental groups when set against those in the NS group (p ranged <0.01 to <0.001). aPTT was significantly longer in the T and HS groups than in that seen in the NS group (p<0.001 for each). Rats in the HS and RL groups showed significantly more bleeding than those in the NS group (p<0.05). Of the treatment groups, the HyperHS group had more brain edema when compared to the NS and RL groups (p<0.05). The proportion of red neuron and necrosis was partially decreased in the treatment groups, with no significant difference determined between the HS, HyperHS, NS and RL groups (p>0.05). In conclusion, study findings support the safely use of normal saline and Ringer lactate solutions in prompt fluid resuscitation where both traumatic brain injury and hemorrhagic shock have occurred, based on the overall advantages pertaining to each critical prognostic parameter.en_US
dc.identifier.doi10.5455/medscience.2020.12.261
dc.identifier.endpage731en_US
dc.identifier.issn2147-0634
dc.identifier.issue3en_US
dc.identifier.startpage725en_US
dc.identifier.trdizinid516075en_US
dc.identifier.urihttps://doi.org/10.5455/medscience.2020.12.261
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/516075
dc.identifier.urihttps://hdl.handle.net/11616/89648
dc.identifier.volume10en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe effects of different fluid resuscitations in the acute phase of combined traumatic brain injury and hemorrhagic shock in an experimental rat modelen_US
dc.typeArticleen_US

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