A new approach to the determination of folic acid at trace levels: using a Fe(III)-folic acid complex to amplify analytical signal

Basit Öğe Kaydı
dc.authoridULUSOY, HALIL IBRAHIM/0000-0002-8742-5145
dc.authoriderdogan, selim/0000-0002-9169-9771
dc.authoridULUSOY, SONGUL/0000-0003-3640-5416
dc.authoridAcidereli, Hilal/0000-0003-4594-1712
dc.authorwosidULUSOY, HALIL IBRAHIM/A-3777-2013
dc.authorwosiderdogan, selim/AAT-2487-2020
dc.authorwosidULUSOY, SONGUL/AAA-9117-2021
dc.contributor.authorUlusoy, Songul
dc.contributor.authorAcidereli, Hilal
dc.contributor.authorErdogan, Selim
dc.contributor.authorUlusoy, Halil Ibrahim
dc.date.accessioned2024-08-04T20:41:47Z
dc.date.available2024-08-04T20:41:47Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA fast, efficient, cost-effective, and environmental-friendly analytical methodology was developed for preconcentration and determination of trace folic acid in food samples prior to high performance liquid chromatography with diode array detection (HPLC-DAD). The method is based on formation of stable complexes between folic acid and Fe(III) ions at pH 8.0. The formed complexes were extracted to a nonionic surfactant phase containing PONPE 7.5. The surfactant rich phase (SRP) was separated by decantation and diluted with 300 mu L of a mixture of 1 M HCl and methanol at a 1 : 1 ratio. The parameters and variables that affected the method were also investigated and optimized in detail. The limit of detection (LOD) of folic acid was 6.06 ng mL(-1), the linear range of quantitation for folic acid was 20-1200 ng mL(-1) and the correlation coefficients of the calibration curves were 0.9976. The average recoveries and relative standard deviations in the analysis of real samples were in the range of 95.1-105.1% and 1.73-5.25%, respectively. After validation of the method was carried out, the method was applied to the determination of folic acid in real samples, including baby foods, vegetables, cereals, and pharmaceutical samples.en_US
dc.description.sponsorshipCumhuriyet University Scientic Research Projects Commission [ECZ-004]en_US
dc.description.sponsorshipThis study has been supported by Cumhuriyet University Scientific Research Projects Commission as the research project with the ECZ-004 code. Authors gratefully thank Prof. Dr Sahin YILDIRIM for his useful comments and contributions to the preparation of the project text.en_US
dc.identifier.doi10.1039/c6ra05286j
dc.identifier.endpage40122en_US
dc.identifier.issn2046-2069
dc.identifier.issue46en_US
dc.identifier.scopus2-s2.0-84971006876en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage40115en_US
dc.identifier.urihttps://doi.org/10.1039/c6ra05286j
dc.identifier.urihttps://hdl.handle.net/11616/97348
dc.identifier.volume6en_US
dc.identifier.wosWOS:000374974300070en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofRsc Advancesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCloud-Point Extractionen_US
dc.subjectWater-Soluble-Vitaminsen_US
dc.subjectSpectrophotometric Methoden_US
dc.subjectFood Samplesen_US
dc.subjectPreconcentrationen_US
dc.subjectChromatographyen_US
dc.subjectSeparationen_US
dc.subjectMethotrexateen_US
dc.subjectTabletsen_US
dc.subjectPlasmaen_US
dc.titleA new approach to the determination of folic acid at trace levels: using a Fe(III)-folic acid complex to amplify analytical signalen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu