Evaluation of antioxidant and antiproliferative activities of 1,2-bis (p-amino-phenoxy) ethane derivative Schiff bases and metal complexes

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dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridKaratepe, Mustafa/0000-0001-6358-5913
dc.authoridPARLAK, AKIF EVREN/0000-0002-2579-9985
dc.authoridYilmaz, Bayram/0000-0002-2674-6535
dc.authoridTuzcu, Mehmet/0000-0002-1329-3143
dc.authoridsekerci, memet/0000-0002-7730-645X
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidKaratepe, Mustafa/HII-5655-2022
dc.authorwosidPARLAK, AKIF EVREN/GNO-9528-2022
dc.authorwosidSekerci, Memet/W-7894-2018
dc.authorwosidYilmaz, Bayram/IXD-3395-2023
dc.authorwosidTuzcu, Mehmet/H-2953-2018
dc.contributor.authorParlak, Akif Evren
dc.contributor.authorCakmak, Haluk
dc.contributor.authorSandal, Suleyman
dc.contributor.authorYilmaz, Bayram
dc.contributor.authorSekerci, Memet
dc.contributor.authorGenc, Zuhal Karagoz
dc.contributor.authorTuzcu, Mehmet
dc.date.accessioned2024-08-04T20:45:32Z
dc.date.available2024-08-04T20:45:32Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, the effects of the two Schiff base derivatives and their metal complexes were tested for MDA concentration, which is an indicator of lipid peroxidation, antioxidant vitamin A, vitamin E, and vitamin C levels in cell culture. A comparison was performed among the groups and it was observed that MDA, vitamin A, vitamin E, and vitamin C concentrations were statistically changed. According to the results, all compounds caused a significant oxidative stress without Zn complexes. Moreover, Mn(II), Cu(II), Zn(II), and Ni(II) complexes of Schiff bases derived from a condensation of 1,2-bis (p-aminophenoxy) ethane with naphthaldehydes and 4-methoxy benzaldehyde were examined in terms of antitumor activity against MCF-7 human breast cancer and L1210 murine leukemia cells. Furthermore, the derivatives were tested for antioxidative and prooxidative effects on MCF-7 breast cancer cells. The compounds which were tested revealed that there was an antitumor activity for MCF-7 and L 1210 cancer cells. Also, some of the compounds induced oxidative harmful.en_US
dc.description.sponsorshipTUBITAK [104T363]; Management Unit of Scientific Research Projects of Firat University (FUBAP) [522]en_US
dc.description.sponsorshipThe TUBITAK, Grant/Award Number: 104T363; Management Unit of Scientific Research Projects of Firat University (FUBAP), Grant/Award Number: 522en_US
dc.identifier.doi10.1002/jbt.22247
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue2en_US
dc.identifier.pmid30431697en_US
dc.identifier.scopus2-s2.0-85056631349en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/jbt.22247
dc.identifier.urihttps://hdl.handle.net/11616/98537
dc.identifier.volume33en_US
dc.identifier.wosWOS:000458367400002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaminophenoxyen_US
dc.subjectantioxidant activityen_US
dc.subjectcanceren_US
dc.subjectcytotoxicityen_US
dc.subjectSchiff baseen_US
dc.titleEvaluation of antioxidant and antiproliferative activities of 1,2-bis (p-amino-phenoxy) ethane derivative Schiff bases and metal complexesen_US
dc.typeArticleen_US

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