Synthesis, Anticonvulsant and Antimicrobial Activities of Some New [1-(2-Naphthyl)-2-(pyrazol-1-yl)ethanone]oxime Ethers

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dc.authoridKarakurt, Arzu/0000-0003-2209-0871
dc.authoridGünal, Selami/0000-0002-4752-5176
dc.authoridsahin, sibel/0000-0003-2745-7871
dc.authoridOzdemir, Zenyep/0000-0003-4559-2305
dc.authorwosidKarakurt, Arzu/ABH-9340-2020
dc.authorwosidGünal, Selami/AAA-7246-2021
dc.authorwosidsahin, sibel/KGL-0953-2024
dc.authorwosidOzdemir, Zenyep/AAJ-6384-2020
dc.contributor.authorOzdemir, Zeynep
dc.contributor.authorKarakurt, Arzu
dc.contributor.authorCalis, Unsal
dc.contributor.authorGunal, Selami
dc.contributor.authorIsik, Samil
dc.contributor.authorSahin, Z. Sibel
dc.contributor.authorDalkara, Sevim
dc.date.accessioned2024-08-04T20:40:09Z
dc.date.available2024-08-04T20:40:09Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, 12 new oxime ether derivatives, which were expected to show anticonvulsant and antimicrobial activities, were synthesized. Oxime ether derivatives were synthesized by the reaction of various alkyl halides with 1-(2-naphthyl)- 2-(pyrazol-1-yl)ethanone oxime. Anticonvulsant activity of the compounds was determined by maximal electroshock (MES) and subcutaneous metrazol (ScM) seizure tests, while neurological disorders were evaluated using rotorod toxicity test according to the ASP of NIH. Compound 1, 6 and 7 showed anticonvulsant activity at 300 mg/kg dose at 4 h, but compounds 1 and 7 showed toxicity at 300 mg/kg dose at half an hour. Antimicrobial activities of the compounds were also determined using agar microdilution method. Compound 1 and 5 were found to have the highest antifungal activity among the other compounds.en_US
dc.description.sponsorshipInonu University Scientific Researches Unit [2009/25]en_US
dc.description.sponsorshipThis project was supported by Inonu University Scientific Researches Unit. (Project no: 2009/25).en_US
dc.identifier.endpage49en_US
dc.identifier.issn1573-4064
dc.identifier.issn1875-6638
dc.identifier.issue1en_US
dc.identifier.pmid24773349en_US
dc.identifier.scopus2-s2.0-84926375777en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage41en_US
dc.identifier.urihttps://hdl.handle.net/11616/96736
dc.identifier.volume11en_US
dc.identifier.wosWOS:000349330100006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofMedicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject(Arylalkyl)azoleen_US
dc.subjectpyrazoleen_US
dc.subjectoxime etheren_US
dc.subjectanticonvulsanten_US
dc.subjectantimicrobialen_US
dc.subjectX-ray crystallographyen_US
dc.titleSynthesis, Anticonvulsant and Antimicrobial Activities of Some New [1-(2-Naphthyl)-2-(pyrazol-1-yl)ethanone]oxime Ethersen_US
dc.typeArticleen_US

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