Short-term effect of topical brinzolamide-timolol fixed combination on ocular surface of glaucoma patients

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dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridBozgul, Pembegul/0000-0002-9427-3610
dc.authoridKantarci, Mecit/0000-0002-1043-6719
dc.authoridGündüz, Abuzer/0000-0003-1752-6810
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidBozgul, Pembegul/AAQ-4951-2020
dc.authorwosidKantarci, Mecit/HLQ-6851-2023
dc.authorwosidGündüz, Abuzer/HLH-2417-2023
dc.contributor.authorFirat, Penpe Gul
dc.contributor.authorSamdanci, Emine
dc.contributor.authorDoganay, Selim
dc.contributor.authorCavdar, Mufide
dc.contributor.authorSahin, Nurdan
dc.contributor.authorGunduz, Abuzer
dc.date.accessioned2024-08-04T20:38:03Z
dc.date.available2024-08-04T20:38:03Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAIM: To evaluate the short-term effect of the fixed combination of brinzolamide-timolol on the ocular surface in glaucoma patients. METHODS: This is a prospective study of 23 eyes of 23 patients with newly diagnosed glaucoma. Schirmer I test, tear break-up time (BUT) measurement, conjunctival impression cytology and central corneal thickness (CCT) measurements were performed in one of the eyes of each patients before and 4 weeks after brinzolamide-timolol fixed combination therapy. All patients were asked to answer the OSDI questionnaire form about the ocular surface symptoms at baseline and at 1 week and 4 weeks follow-up visits. RESULTS: After brinzolamide-timolol fixed combination theraphy, Schirmer I, BUT and CCT values decreased but the only statistically significant decrease was seen in BUT test (P=0.03). OSDI scores increased during the follow-up but this increase was not statistically significant (P=0.22, P=0.42 respectively). Impression cytology findings ranged from 0.78 +/- 0.42 to 0.95 +/- 0.36 according to the Nelson classification. There was no statistically significant difference between baseline and 4 weeks follow up in impression cytology grades (P=0.15). CONCLUSION: The results of our study indicate that short-term use of brinzolamide-timolol fixed combination theraphy does not have a profound effect on ocular surface except BUT values.en_US
dc.identifier.doi10.3980/j.issn.2222-3959.2012.06.12
dc.identifier.endpage718en_US
dc.identifier.issn2222-3959
dc.identifier.issn2227-4898
dc.identifier.issue6en_US
dc.identifier.pmid23275906en_US
dc.identifier.scopus2-s2.0-84894547415en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage714en_US
dc.identifier.urihttps://doi.org/10.3980/j.issn.2222-3959.2012.06.12
dc.identifier.urihttps://hdl.handle.net/11616/96356
dc.identifier.volume5en_US
dc.identifier.wosWOS:000312745400012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIjo Pressen_US
dc.relation.ispartofInternational Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfixed combination antiglaucoma drugen_US
dc.subjectocular surfaceen_US
dc.subjectimpression cytologyen_US
dc.titleShort-term effect of topical brinzolamide-timolol fixed combination on ocular surface of glaucoma patientsen_US
dc.typeArticleen_US

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