Cerebral diffusional changes in the early phase of anthrax: Is cutaneous anthrax only limited to skin?

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dc.authoridBayindir, Yasar/0000-0003-3930-774X
dc.authoridKarakas, Hakki/0000-0002-1328-8520
dc.authorwosidBayindir, Yasar/T-1523-2017
dc.contributor.authorKarakas, HM
dc.contributor.authorBayindir, Y
dc.contributor.authorFirat, AK
dc.contributor.authorYagmur, C
dc.contributor.authorAlkan, A
dc.contributor.authorKayabas, U
dc.date.accessioned2024-08-04T20:15:23Z
dc.date.available2024-08-04T20:15:23Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives. Characteristics of cerebral diffusion in the acute period of the anthrax infection were investigated to understand the pathophysiology of the disease. Methods. Six cutaneous anthrax patients (mean age: 33.3, SD: 18.1) and six healthy control subjects (mean age: 33.7, SS: 19.6) were examined at the acute phase of the infection with diffusion weighted imaging on 1.5 T scanner. ADC values were measured from five different cerebral locations. T-tests, Logistic regression and ROC curves were used. Results. Anthrax patients were significantly different than controls regarding cortical ADC values (p < 0.05). Logistic regression model accurately classified five out of the six anthrax cases (83.3%). A cut-off value of 574 mm(2)/s x 10(-3) was found by using ROC curve coordinates. A sensitivity of 100% and a specificity of 67% were attained by means of this value. Conclusions. This study shows the existence of cerebral parenchymal. changes at microstructural. level in cutaneous anthrax without neurological findings. These changes are possibly related to the components of the toxin. Our results support the general but unproven opinion that anthrax treatment does not change the existence and the effects of the toxin. Pathophysiological. mechanisms towards classification should therefore be reviewed. (c) 2005 The British Infection Society. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jinf.2005.07.027
dc.identifier.endpage358en_US
dc.identifier.issn0163-4453
dc.identifier.issue5en_US
dc.identifier.pmid16219360en_US
dc.identifier.scopus2-s2.0-33645931702en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage354en_US
dc.identifier.urihttps://doi.org/10.1016/j.jinf.2005.07.027
dc.identifier.urihttps://hdl.handle.net/11616/94360
dc.identifier.volume52en_US
dc.identifier.wosWOS:000237636600008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co Ltden_US
dc.relation.ispartofJournal of Infectionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcutaneous anthraxen_US
dc.subjectbrain parenchymaen_US
dc.subjectdiffusion weighted imagingen_US
dc.subjectapparent diffusion coefficienten_US
dc.titleCerebral diffusional changes in the early phase of anthrax: Is cutaneous anthrax only limited to skin?en_US
dc.typeArticleen_US

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