An experimental study: Diabetic nephropathy and oxidative damage relationship

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dc.contributor.authorTanbek, Kevser
dc.contributor.authorSandal, Suleyman
dc.date.accessioned2024-08-04T19:42:43Z
dc.date.available2024-08-04T19:42:43Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: The increase of oxidatif stress caused by hyperglycemia in diabetes contributes to diabetic complications such as nephropathy. Experimental Diabetes Mellitus (DM) was induced with streptozotocin. Thioctic acid (TA), which has antioxidant properties, is a vital cofactor of mitochondrial respiration enzymes. This study investigated whether TA administration could reduce oxidative stress to treat diabetic nephropathy. Materials and Methods: 40 male Wistar albino rats were divided to groups: Control, DM, TA and DM+TA. TA and DM+TA group was administered 100 mg/kg/day TA daily, and blood glucose was assessed for six weeks. The superoxide dismutase, glutathione peroxidase and catalase activities, glutathione levels, malondialdehyde (MDA), protein carbonyl (PC), total antioxidant (TAS), total oxidant status (TOS) and OSI also were evaluated. Results: MDA and PC were increased, and antioxidant capacity was decreased in the diabetic groups compared to Control (p <0.05). In the DM+TA group, MDA, PC and TOS were decreased and TAS was increased compared to the DM group (p <0.05). Conclusion: TA exhibited a curative effect on diabetic nephropathy by increasing an tioxidant activity and reducing oxidative damage.en_US
dc.identifier.doi10.5455/annalsmedres.2022.12.376
dc.identifier.endpage454en_US
dc.identifier.issn2636-7688
dc.identifier.issue4en_US
dc.identifier.startpage449en_US
dc.identifier.trdizinid1165220en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2022.12.376
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1165220
dc.identifier.urihttps://hdl.handle.net/11616/88607
dc.identifier.volume30en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAn experimental study: Diabetic nephropathy and oxidative damage relationshipen_US
dc.typeArticleen_US

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