A Multicenter Study of 1144 Patients with Cerebral Venous Thrombosis: The VENOST Study

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dc.authoridAfsar, Nazire/0000-0001-8123-8560
dc.authoridOZTURK, SEREFNUR/0000-0001-8986-155X
dc.authoridYılmaz, Arda/0000-0002-4679-1632
dc.authoridKablan, Yüksel/0000-0002-5581-2968
dc.authoriddemir, serkan/0000-0003-4395-5141
dc.authoridBatur Caglayan, Hale/0000-0002-3279-1842
dc.authoridYesilot, Nilufer/0000-0002-9655-9487
dc.authorwosidNazliel, Bijen/ABI-2924-2020
dc.authorwosidAfsar, Nazire/AAN-2537-2020
dc.authorwosidOZDAG, Mehmet Fatih/Q-3247-2016
dc.authorwosidOZTURK, SEREFNUR/AAG-4973-2019
dc.authorwosidYılmaz, Arda/A-6263-2016
dc.authorwosidAYTAC, EMRAH/X-1420-2018
dc.authorwosidKablan, Yüksel/AAB-5049-2021
dc.contributor.authorDuman, Taskin
dc.contributor.authorUluduz, Derya
dc.contributor.authorMidi, Ipek
dc.contributor.authorBektas, Hesna
dc.contributor.authorKablan, Yuksel
dc.contributor.authorGoksel, Basak K.
dc.contributor.authorMilanlioglu, Aysel
dc.date.accessioned2024-08-04T20:43:11Z
dc.date.available2024-08-04T20:43:11Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Based on a number of small observational studies, cerebral venous sinus thrombosis has diverse clinical and imaging features, risk factors, and variable outcome. In a large, multicenter cerebral venous thrombosis (VENOST) study, we sought to more precisely characterize the clinical characteristics of Caucasian patients. Methods: All data for the VENOST study were collected between the years 2000 and 2015 from the clinical follow-up files. Clinical and radiological characteristics, risk factors, and outcomes were compared in terms of age and sex distribution. Results: Among 1144 patients 68% were women, and in older age group (>50 years) male patients were more prevalent (16.6% versus 27.8%). The most frequent symptoms were headache (89.4%) and visual field defects (28.9%) in men, and headache (86.1%) and epileptic seizures (26.8%) in women. Gynecological factors comprised the largest group in women, in particular puerperium (18.3%). Prothrombotic conditions (26.4%), mainly methylenetetrahydrofolate reductase mutation (6.3%) and Factor V Leiden mutation (5.1%), were the most common etiologies in both genders. 8.1% of patients had infection-associated and 5.2% had malignancy-related etiology that was significantly higher in men and older age group. Parenchymal involvement constitutively hemorrhagic infarcts, malignancy, and older age was associated with higher Rankin score. Epileptic seizures had no effect on prognosis. Conclusions: Clinical and radiological findings were consistent with previous larger studies but predisposing factors were different with a higher incidence of puerperium. Oral contraceptive use was not a prevalent risk factor in our cohort. Malignancy, older age, and hemorrhagic infarcts had worse outcome. (c) 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jstrokecerebrovasdis.2017.04.020
dc.identifier.endpage1857en_US
dc.identifier.issn1052-3057
dc.identifier.issn1532-8511
dc.identifier.issue8en_US
dc.identifier.pmid28583818en_US
dc.identifier.scopus2-s2.0-85020109081en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1848en_US
dc.identifier.urihttps://doi.org/10.1016/j.jstrokecerebrovasdis.2017.04.020
dc.identifier.urihttps://hdl.handle.net/11616/97838
dc.identifier.volume26en_US
dc.identifier.wosWOS:000407019200036en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Stroke & Cerebrovascular Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCerebrovascular diseaseen_US
dc.subjectcerebral venous sinus thrombosisen_US
dc.subjectclinicen_US
dc.subjectimagingen_US
dc.titleA Multicenter Study of 1144 Patients with Cerebral Venous Thrombosis: The VENOST Studyen_US
dc.typeArticleen_US

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