THE EFFECTS OF EXOGENOUS ADRENOMEDULLIN AND L-NAME ON ANTIOXIDANT DEFENCE SYSTEM OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND LIPID PARAMETERS OF SERUM IN RAT

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dc.authoridYuksel, Sengul/0000-0002-7190-431X
dc.authoridAsma, Dilek/0000-0002-3866-3016
dc.authorwosidYuksel, Sengul/ABI-2182-2020
dc.authorwosidAsma, Dilek/AAA-5294-2021
dc.contributor.authorAsma, Dilek
dc.contributor.authorYuksel, Sengul
dc.date.accessioned2024-08-04T21:02:02Z
dc.date.available2024-08-04T21:02:02Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of our study was to investigate the contribution of exogenous adrenomedullin (ADM): an antioxidant, and N sup omega nitro-L-arginine methyl ester (L-NAME); the nitric oxide synthase (NOS) enzyme inhibitor, to balance the oxidant/antioxidant status in hypothalamus and adrenal medulla, which are both key components of the hypothalamic-pituitary-adrenal (HPA) axis and affects some lipid metabolic mediators. Thirty six male albino Spraque-Dawley rats were randomly divided into three groups: the control group, the ADM group (8 nmol/kg, i.p.), and the L-NAME group (2 ml/kg, i.p.). Measurements of tissue superoxide dismutase (SOD), catalase (CAT), glutathion S-transferase (GST) and glutathion reductase (GR) activities and glutathione (GSH) were performed in tissues using chemical protocols. The biochemical analyses for total lipid, cholesterol, triglycerides, HDL, VLDL, and LDL were conducted on an auto-analyser. Administering exogenous ADM and L-NAME caused synergic changes in the tissues, antioxidative enzyme activities, and altered serum lipoprotein profiles in rats. In the adrenal medulla and hypothalamus of the experimental groups, SOD and GST activities decreased significantly, while the CAT and GR activities increased. The amount of GSH was enhanced in the both tissues in the ADM group only, while the amount was decreased for the hypothalamus of the L-NAME group. After the treatment, the cholesterol (of L-NAME group), triglyceride, total lipid, and VLDL parameters varied significantly, but there was no significant difference between the HDL and LDL among the groups.en_US
dc.description.sponsorshipInonu University Academic Research Project Uniten_US
dc.description.sponsorshipThis study was supported by Inonu University Academic Research Project Unit.en_US
dc.identifier.endpage1981en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue8en_US
dc.identifier.startpage1976en_US
dc.identifier.urihttps://hdl.handle.net/11616/104400
dc.identifier.volume20en_US
dc.identifier.wosWOS:000294318900016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdrenomedullinen_US
dc.subjectL-NAMEen_US
dc.subjectglutathioneen_US
dc.subjectantioxidant enzymesen_US
dc.subjectlipid metabolismen_US
dc.subjectraten_US
dc.titleTHE EFFECTS OF EXOGENOUS ADRENOMEDULLIN AND L-NAME ON ANTIOXIDANT DEFENCE SYSTEM OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND LIPID PARAMETERS OF SERUM IN RATen_US
dc.typeArticleen_US

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