Humanin's impact on pain markers and neuronal viability in diabetic neuropathy model

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dc.authoridKelestemur, Mirac/0000-0003-0455-4521
dc.authoridADAM, Muhammed/0000-0002-5080-5160
dc.authorwosidKelestemur, Mirac/AAK-8577-2021
dc.contributor.authorKelestemur, Muhammed Mirac
dc.contributor.authorBulut, Ferah
dc.contributor.authorBilgin, Batuhan
dc.contributor.authorHekim, Munevver Gizem
dc.contributor.authorAdam, Muhammed
dc.contributor.authorOzcan, Sibel
dc.contributor.authorBeker, Mustafa Caglar
dc.date.accessioned2024-08-04T20:55:55Z
dc.date.available2024-08-04T20:55:55Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective This study investigates the impact of chronic humanin (HN) treatment on pain-related markers (NMDA, substance P, TRPV1, and IL-1 beta) in diabetic mice's dorsal root ganglia (DRG). Additionally, we assess the effects of HN on cellular viability in DRG neurons. Methods In vivo experiments involved 15 days of HN administration (4 mg/kg) to diabetic mice (n = 10). Protein levels of NMDA, IL-1 beta, TRPV1, and substance P were measured in diabetic DRG. In vitro experiments explored HN's impact on apoptosis and cellular viability, focusing on the JAK2/STAT3 pathway. Results Humanin significantly reduced the elevated expression of NMDA, IL-1 beta, TRPV1, and substance P induced by diabetes (p < .05). Furthermore, HN treatment increased cellular viability in DRG neurons through JAK2/STAT3 pathway activation (p < .05). Conclusion These findings highlight the significance of understanding mitochondrial function and pain markers, as well as apoptosis in diabetes. The study provides insights for managing the condition and its complications.en_US
dc.description.sponsorshipTurkish Scientific Technical Research Organization (TUBITAK) [119R084]en_US
dc.description.sponsorshipThis study was supported by Turkish Scientific Technical Research Organization (TUBITAK) under Project No.: 119R084.en_US
dc.identifier.doi10.1080/13813455.2024.2336922
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.pmid38599217en_US
dc.identifier.scopus2-s2.0-85189896372en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/13813455.2024.2336922
dc.identifier.urihttps://hdl.handle.net/11616/101922
dc.identifier.wosWOS:001200461300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArchives of Physiology and Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHumaninen_US
dc.subjectdorsal root gangliaen_US
dc.subjectpain markersen_US
dc.subjectapoptosisen_US
dc.subjectcell viabilityen_US
dc.subjectdiabetic neuropathyen_US
dc.titleHumanin's impact on pain markers and neuronal viability in diabetic neuropathy modelen_US
dc.typeArticleen_US

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