Investigation of antioxidant properties of some 6-(?-aminobenzyl) thiazolo[3,2-b]-1,2,4-triazole-5-ol compounds

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dc.authoridAKTAY, Goknur/0000-0002-1646-8674
dc.contributor.authorAktay, Goknur
dc.contributor.authorTozkoparan, Birsen
dc.contributor.authorErtan, Mevlut
dc.date.accessioned2024-08-04T20:32:13Z
dc.date.available2024-08-04T20:32:13Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPromising antiinflammatory activity together with low ulcerogenic properties of some Michael addition products of thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones which have been synthesized in our previous study, prompted us to investigate their antioxidant properties. Since compound Ib has both antioxidant and antiinflammatory activities beside the lowest ulcerogenic incidence, it was selected for investigation of its inhibitory effect on various cyclooxygenase ezymes. It was found that while it did not inhibit cyclooxygenase-1 (COX-1) enzyme, there was a small inhibitory effect (17%) on COX-2 enzyme. We concluded that the diminished harmful effects on the stomach of this novel antiinflammatory compound were related to its antioxidant properties since it is ineffective on COX-1 enzyme. In conclusion, the compounds having both antioxidant and antiinflammatory activities with a lack of COX-1 enzyme inhibitory effect may improve the gastrointestinal safety profile of such compounds.en_US
dc.description.sponsorshipHacettepe University Scientific Research Unit [00.02.301.007]en_US
dc.description.sponsorshipThis study was supported by Hacettepe University Scientific Research Unit (Project No: 00.02.301.007).en_US
dc.identifier.doi10.1080/14756360802519798
dc.identifier.endpage902en_US
dc.identifier.issn1475-6366
dc.identifier.issue3en_US
dc.identifier.pmid18951285en_US
dc.identifier.scopus2-s2.0-70749085052en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage898en_US
dc.identifier.urihttps://doi.org/10.1080/14756360802519798
dc.identifier.urihttps://hdl.handle.net/11616/94918
dc.identifier.volume24en_US
dc.identifier.wosWOS:000266040700037en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntiinflammatoryen_US
dc.subjectantioxidanten_US
dc.subjectcondansed thiazolo-triazole compoundsen_US
dc.subjectethanolen_US
dc.subjectcyclooxygenaseen_US
dc.subjectCOX-1/2en_US
dc.titleInvestigation of antioxidant properties of some 6-(?-aminobenzyl) thiazolo[3,2-b]-1,2,4-triazole-5-ol compoundsen_US
dc.typeArticleen_US

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