Synthesis and analgesic, antiinflammatory and antimicrobial evaluation of 6-substituted-3(2H)-pyridazinone-2-acetyl-2- (substituted benzal) hydrazone derivatives

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dc.authorscopusid57213636835
dc.authorscopusid7003767561
dc.authorscopusid6602307926
dc.contributor.authorÖzdemir Z.
dc.contributor.authorGökçe M.
dc.contributor.authorKarakurt A.
dc.date.accessioned2024-08-04T20:01:01Z
dc.date.available2024-08-04T20:01:01Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn present study a series of new 6-substituted-3(2H)-pyridazinone-2-acetyl-2- (substituted benzal) hydrazone derivatives were synthesized and evaluated for analgesic, and anti-inflammatory and antimicrobial activities. The structures of these new pyridazinone derivatives were confirmed by their IR, 1H-NMR spectra and elementary analysis. Analgesic activity of new pyridazinone derivatives have been tested by the phenylbenzoquinone-induced writhing test (PBQ test), and anti-inflammatory activity have been evaluated the carragenan-induced paw edema method. A significant dependence of the anti-inflammatory and analgesic effects on the substituents has been observed. The pharmacological study of these compounds confirms that modification of the atom or chemical group at phenyl ring of benzalhydrazon moiety influences analgesic and anti-inflammatory activities. Synthesized compounds have been shown moderate antimicrobial activities.en_US
dc.identifier.endpage122en_US
dc.identifier.issn1300-4182
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84926198001en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage111en_US
dc.identifier.urihttps://hdl.handle.net/11616/91195
dc.identifier.volume37en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSociety of Pharmaceutical Sciences of Ankara (FABAD)en_US
dc.relation.ispartofFabad Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject6-Substituted-3 (2H) -pyridazinonesen_US
dc.subjectAnalgesic activityen_US
dc.subjectAnti-inflammatory activityen_US
dc.subjectBenzaldehyde hydrazonesen_US
dc.titleSynthesis and analgesic, antiinflammatory and antimicrobial evaluation of 6-substituted-3(2H)-pyridazinone-2-acetyl-2- (substituted benzal) hydrazone derivativesen_US
dc.typeArticleen_US

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