Comparison of Nerve, Vessel, and Cartilage Grafts in Promoting Peripheral Nerve Regeneration

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dc.authoridozcan, abdulcemal/0000-0002-6759-7556
dc.authoridKamisli, Suat/0000-0003-4281-3301
dc.authoridGül, Mehmet/0000-0002-1374-0783;
dc.authorwosidozcan, abdulcemal/B-1348-2008
dc.authorwosidKamisli, Suat/AAC-2706-2021
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidKamisli, Suat/JZT-8388-2024
dc.authorwosidFirat, Cemal/D-1292-2012
dc.authorwosidKamisli, Suat/JVN-4663-2024
dc.contributor.authorFirat, Cemal
dc.contributor.authorGeyik, Yilmaz
dc.contributor.authorAytekin, Ahmet Hamdi
dc.contributor.authorGul, Mehmet
dc.contributor.authorKamisli, Suat
dc.contributor.authorYigitcan, Birgul
dc.contributor.authorOzcan, Cemal
dc.date.accessioned2024-08-04T20:39:44Z
dc.date.available2024-08-04T20:39:44Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPeripheral nerve injury primarily occurs due to trauma as well as factors such as tumors, inflammatory diseases, congenital deformities, infections, and surgical interventions. The surgical procedure to be performed as treatment depends on the etiology, type of injury, and the anatomic region. The goal of treatment is to minimize loss of function due to motor and sensory nerve loss at the distal part of the injury. Regardless of the cause of the injury, the abnormal nerve regeneration due to incomplete nerve regeneration, optimal treatment of peripheral nerve injuries should provide adequate coaptation of proximal and distal sides without tension, preserving the neurotrophic factors within the repair line. The gold standard for the treatment of nerve defects is the autograft; however, due to denervation of the donor site, scarring, and neuroma formation, many studies have aimed to develop simpler methods, better functional results, and less morbidity. In this study, a defect 1 cm in length was created on the sciatic nerve of rats. The rats were treated with the following procedures: group 1, autograft; group 2, allogeneic aorta graft; group 3, diced cartilage graft in allogeneic aorta graft; and group 4, tubularized cartilage graft in allogeneic aorta graft. Group 5 was the control group. The effects of cartilage tissue in nerve regeneration were evaluated by functional and histomorphological methods. Group 1, for which the repair was performed with an autograft, was evaluated to be the most similar to the control group. There was not a statistically significant difference in myelination and Schwann cell rates between group 2, in which an allogeneic aorta graft was used, and group 3, in which diced cartilage in an allogeneic aorta graft was used. In group 4, myelination and Schwann cell formation were observed; however, they were scattered and irregular, likely due to increased fibrosis. In all of the groups, nerve regeneration at various rates was observed both functionally and histomorphologically. This study demonstrates that cartilage tissue has promoting effects in nerve regeneration.en_US
dc.identifier.doi10.1097/SAP.0b013e31829fd2be
dc.identifier.endpage61en_US
dc.identifier.issn0148-7043
dc.identifier.issn1536-3708
dc.identifier.issue1en_US
dc.identifier.pmid23917545en_US
dc.identifier.scopus2-s2.0-84902539289en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage54en_US
dc.identifier.urihttps://doi.org/10.1097/SAP.0b013e31829fd2be
dc.identifier.urihttps://hdl.handle.net/11616/96479
dc.identifier.volume73en_US
dc.identifier.wosWOS:000338342000014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnnals of Plastic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectperipheral nerve regenerationen_US
dc.subjectcartilage graften_US
dc.subjectnerve graften_US
dc.subjectvessel graften_US
dc.subjectmyelinationen_US
dc.titleComparison of Nerve, Vessel, and Cartilage Grafts in Promoting Peripheral Nerve Regenerationen_US
dc.typeArticleen_US

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