Surgical Removal of Endometrioma Decreases the NF-kB1 (p50/105) and NF-kB p65 (Rel A) Expression in the Eutopic Endometrium During the Implantation Window

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dc.authoridCelik, ebru/0000-0002-0774-4294
dc.authoridKaraer, Abdullah/0000-0002-2010-6211
dc.authoridUnlu, Mehmet Cihat/0000-0001-5507-3993
dc.authoridTURKCUOGLU, ILGIN/0000-0002-8342-1956
dc.authoridAYDIN, Nasuhi/0000-0003-3145-2432
dc.authorwosidAYDIN, Nasuhi Engin/L-1607-2019
dc.authorwosidUlas, mustafa/KIE-9518-2024
dc.authorwosidCelik, ebru/X-4343-2019
dc.authorwosidÖzerol, İbrahim Halil/ABI-8015-2020
dc.authorwosidAydin, Nasuhi E/B-6536-2012
dc.authorwosidKaraer, Abdullah/ABI-4667-2020
dc.authorwosidSimsek, Yavuz/AAH-9894-2021
dc.contributor.authorCelik, Onder
dc.contributor.authorCelik, Ebru
dc.contributor.authorTurkcuoglu, Ilgin
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorUlas, Mustafa
dc.contributor.authorSimsek, Yavuz
dc.contributor.authorKaraer, Abdullah
dc.date.accessioned2024-08-04T20:37:38Z
dc.date.available2024-08-04T20:37:38Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe aimed to investigate whether the surgical removal of endometrioma alters the nuclear factor-kappa B1 (NF-kB1; p50/105) and NF-kB p65 (Rel A) expression in the eutopic endometrium of infertile women with endometrioma before and after laparoscopic removal of the ovarian endometrioma during the mid-secretory phase. Infertile women with endometrioma (n = 15) were enrolled. Infertile patients with nonendometriotic ovarian cyst (n = 10) and healthy fertile women (n = 10) were recruited as controls. Endometrial samples were obtained before and 3 months after the laparoscopic cystectomy. The NF-kB1 (p50/105) levels were analyzed by enzyme-linked immunosorbent assay (ELISA) in the endometrium of all groups before and after laparoscopic ovarian cystectomy during implantation window. Expression of NF-kB1 (p50/105) in eutopic endometrium was significantly higher in infertile women with endometrioma compared to nonendometriotic cyst and fertile controls (P < .05). Laparoscopic cystectomy resulted in a significant decrease in NF-kB1 expression in women with endometrioma. The NF-kB p65 (Rel A) immunoreactivity of eutopic endometrium decreased significantly subsequent to the surgical removal of the endometrioma. In conclusion, increased endometrial NF-kB expression may contribute to endometriosis-associated infertility.en_US
dc.identifier.doi10.1177/1933719112466307
dc.identifier.endpage770en_US
dc.identifier.issn1933-7191
dc.identifier.issn1933-7205
dc.identifier.issue7en_US
dc.identifier.pmid23221171en_US
dc.identifier.scopus2-s2.0-84878852476en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage762en_US
dc.identifier.urihttps://doi.org/10.1177/1933719112466307
dc.identifier.urihttps://hdl.handle.net/11616/96090
dc.identifier.volume20en_US
dc.identifier.wosWOS:000319926200005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofReproductive Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectendometriomaen_US
dc.subjecteutopic endometriumen_US
dc.subjectlaparoscopyen_US
dc.subjectNF-kB1en_US
dc.subjectNF-kB p65 (Rel A)en_US
dc.titleSurgical Removal of Endometrioma Decreases the NF-kB1 (p50/105) and NF-kB p65 (Rel A) Expression in the Eutopic Endometrium During the Implantation Windowen_US
dc.typeArticleen_US

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