Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachloride administration in Wistar rats

Basit Öğe Kaydı
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.contributor.authorCetin, Asli
dc.contributor.authorCiftci, Osman
dc.contributor.authorOtlu, Ali
dc.date.accessioned2024-08-04T20:41:48Z
dc.date.available2024-08-04T20:41:48Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: In the current study, the protective effect of hesperidin (HP) on carbon tetrachloride (CCl4)-induced hepatotoxicity in rats was investigated. Material and methods: Twenty-eight rats were divided equally into four groups. The first group was kept as a control and given only vehicle. In the second, rats were orally administered 50 mg/kg/day HP for 10 days. Carbon tetrachloride was given in a single intraperitoneal injection at the dose of 2 ml/kg in the third group. In the fourth group, the rats were treated with equal doses of CCl4 and HP. Results: It was found that CCl4 induced oxidative stress via a significant increase in the formation of thiobarbituric acid-reactive substances (TBARS) and caused a significant decline in the levels of glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) in rats. In contrast, HP blocked these toxic effects induced by CCl4, causing an increase in GSH, CAT and SOD levels and decreased formation of TBARS (p < 0.01). In addition, histopathological damage increased with CCl4 treatment. In contrast, HP treatment eliminated the effects of CCl4 and stimulated anti-apoptotic events, as characterized by reduced caspase-3 activation. Conclusions: The current study demonstrated that CCl4-induced hepatotoxicity can be prevented with HP treatment. Thus, co-administration of HP with CCl4 may be useful for attenuating the negative effects of CCl4 on the liver.en_US
dc.identifier.doi10.5114/aoms.2015.49484
dc.identifier.endpage493en_US
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue3en_US
dc.identifier.pmid27279838en_US
dc.identifier.scopus2-s2.0-84973468648en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage486en_US
dc.identifier.urihttps://doi.org/10.5114/aoms.2015.49484
dc.identifier.urihttps://hdl.handle.net/11616/97361
dc.identifier.volume12en_US
dc.identifier.wosWOS:000376210500003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofArchives of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectliveren_US
dc.subjecthesperidinen_US
dc.subjectcarbon tetrachlorideen_US
dc.subjecthepatotoxicityen_US
dc.titleProtective effect of hesperidin on oxidative and histological liver damage following carbon tetrachloride administration in Wistar ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu