Level of serum neutrophil gelatinase-associated lipocalin in childhood asthma

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dc.authoridAkelma, Zülfikar/0000-0003-0140-5053
dc.authoridKanburoglu, Mehmet Kenan/0000-0001-6859-6689
dc.authorwosidAkelma, Zülfikar/GPT-0838-2022
dc.authorwosidKanburoglu, Mehmet Kenan/B-9255-2018
dc.contributor.authorAkelma, A. Z.
dc.contributor.authorKanburoglu, M. K.
dc.contributor.authorCizmeci, M. N.
dc.contributor.authorMete, E.
dc.contributor.authorCatal, F.
dc.contributor.authorTufan, N.
dc.date.accessioned2024-08-04T20:40:08Z
dc.date.available2024-08-04T20:40:08Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The role of neutrophil gelatinase-associated lipocalin (NGAL) in childhood asthma remains unknown. This study aimed to measure the serum levels of NGAL in children with asthma and to investigate the correlation between NGAL and transforming growth factor beta 1 (TGF-beta 1), a good indicator of airway remodeling in children with asthma. Methods: This prospective, cross-sectional study was conducted on 75 children. Serum NGAL and TGF-beta 1 concentrations were measured by the ELISA method. Complete blood count, high sensitive C reactive protein (hsCRP), eosinophil cationic protein (ECP), and total serum IgE were investigated in the study population. Atopy in the asthma group was investigated using a skin prick test and specific IgE measurements. Results: Forty-three asthmatic children and 32 healthy children were enrolled in the study. Total eosinophil numbers, white blood cell count, total serum IgE levels and ECP levels were significantly higher in the asthma group than in the control group (p < 0.05). Similarly, serum TGF-beta 1 levels were significantly higher in children with asthma (p = 0.012). The difference in NGAL levels between the groups was insignificant (p = 0.268). NGAL levels did not show a significant correlation with total IgE, ECP, eosinophil numbers and TGF-beta 1 levels (p > 0.05). Conclusion: As a conclusion, while elevated TGF-beta 1 levels in children with asthma might be regarded as an indicator of airway remodeling, we did not find a similar prediction strength for NGAL. Further studies are required to better identify the role of NGAL in childhood asthma and to determine its potential use as a clinical marker. (C) 2013 SEICAR Published by Elsevier Espana, S.L.U. All rights reserved.en_US
dc.description.sponsorshipScientific Research Fund of Fatih Universityen_US
dc.description.sponsorshipThis study is supported by the Scientific Research Fund of Fatih University.en_US
dc.identifier.doi10.1016/j.aller.2013.11.004
dc.identifier.endpage146en_US
dc.identifier.issn0301-0546
dc.identifier.issn1578-1267
dc.identifier.issue2en_US
dc.identifier.pmid24637108en_US
dc.identifier.scopus2-s2.0-84926258885en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage142en_US
dc.identifier.urihttps://doi.org/10.1016/j.aller.2013.11.004
dc.identifier.urihttps://hdl.handle.net/11616/96734
dc.identifier.volume43en_US
dc.identifier.wosWOS:000352746400005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Doyma Slen_US
dc.relation.ispartofAllergologia Et Immunopathologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsthmaen_US
dc.subjectChildrenen_US
dc.subjectExtracellular matrix proteinen_US
dc.subjectLipocalin-2en_US
dc.subjectRemodelingen_US
dc.titleLevel of serum neutrophil gelatinase-associated lipocalin in childhood asthmaen_US
dc.typeArticleen_US

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