Adrenomedullin and total nitrite levels in children with acute rheumatic fever

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dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authoridBalat, Ayse/0000-0002-8904-1348;
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.authorwosidcekmen, mustafa baki/G-6122-2011
dc.authorwosidGuler, Elif/C-2418-2016
dc.authorwosidBalat, Ayse/JOZ-8426-2023
dc.authorwosidCoşkun, M. Yavuz/AAI-8261-2020
dc.contributor.authorBalat, A
dc.contributor.authorKilinc, M
dc.contributor.authorCekmen, MB
dc.contributor.authorGüler, E
dc.contributor.authorYürekli, M
dc.contributor.authorSahinöz, S
dc.contributor.authorCoskun, Y
dc.date.accessioned2024-08-04T20:14:45Z
dc.date.available2024-08-04T20:14:45Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To investigate the levels of adrenomedullin (AM) and total nitrite, a stable product of nitric oxide (NO), in children with acute rheumatic fever (ARF). Design and methods: Eleven children with ARF were investigated in comparison with 14 healthy controls. Adrenomedullin was detected by HPLC, while total nitrite was quantitated by the Griess reaction. Results: Plasma urinary AM and total nitrite levels were significantly higher in children with ARE, irrespective of whether they were in the acute or convalescent phase of disease. Plasma AM (pmol/mL) levels were 49.19 +/- 3.23 in the acute phase, 44.52 +/- 4.26 in the convalescent phase, 35.49 +/- 3.43 in controls, and urinary AM excretion (pmol/mg creatinine) was 43.45 +/- 18.40 in the acute phase, 32.38 +/- 15.37 in the convalescent phase, and 24.84 +/- 11.38 in controls. Plasma total nitrite levels (mu mol/L) were 75.37 +/- 13.13 in the acute phase, 59.81 +/- 12.78 in the convalescent phase, and 41.09 +/- 10.27 in controls. Urinary total nitrite excretion (mu mol/mg creatinine) was 3.82 +/- 1.56 in the acute phase, 2.15 +/- 0.58 in the convalescent phase, and 1.33 +/- 0.61 in controls. The differences were statistically significant for all (P < 0.05). Conclusion: This study considered that AM and NO may have a role in the immunoinflammatory process of ARF. (c) 2005 The Canadian Society of Clinical Chemists. All rights reserved.en_US
dc.identifier.doi10.1016/j.clinbiochem.2005.01.006
dc.identifier.endpage530en_US
dc.identifier.issn0009-9120
dc.identifier.issue6en_US
dc.identifier.pmid15885231en_US
dc.identifier.scopus2-s2.0-18844416080en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage526en_US
dc.identifier.urihttps://doi.org/10.1016/j.clinbiochem.2005.01.006
dc.identifier.urihttps://hdl.handle.net/11616/93944
dc.identifier.volume38en_US
dc.identifier.wosWOS:000229294900006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofClinical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacute rheumatic feveren_US
dc.subjectadrenomedullinen_US
dc.subjectnitric oxideen_US
dc.titleAdrenomedullin and total nitrite levels in children with acute rheumatic feveren_US
dc.typeArticleen_US

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