The relationship between cognitive function and functional capacity, and cognitive reserve and reaction time in patients with multiple sclerosis

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dc.contributor.authorCandiri, Busra
dc.contributor.authorRamazanoglu, Engin
dc.contributor.authorTalu, Burcu
dc.contributor.authorTecellioglu, Mehmet
dc.date.accessioned2026-04-04T13:33:39Z
dc.date.available2026-04-04T13:33:39Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground Cognitive dysfunction is frequently seen in multiple sclerosis (MS). However, there are conflicting findings regarding the factors it is associated with. Objective To investigate the relationship between aerobic capacity, strength, disability, depression, fatigue, and cognitive reserve and function. Methods The mobile applications Trail Making Test (TMT A-B), Digit Span Test (DST), Visuospatial Memory Test (VSMT), and Tap Fast were used in the cognitive function evaluation. Functional performance was assessed with the 6-minute walk test (6MWT), 5-Time Sit-to-Sand (5STS) test, and grip strength. Cognitive Reserve Index (CRI), Beck Depression Inventory, Fatigue Severity Scale (FSS), and Nottingham Health Profile were also used. Results A significant difference was found between the MS and control groups only in the 6MWT, STS-5, grip strength, TMT, VSMT, and Tap Fast. Good correlation was found between the TMT-A and 6MWT and physical mobility. A fair correlation was shown between grip strength, energy, and pain status. A good correlation was found between TMT-B and 6MWT, and a fair relationship with disability, cognitive reserve, and pain. Good correlation was observed between the DST and 6MWT, left grip strength, pain, and energy status; fair correlations were found between right grip strength, cognitive reserve, and physical mobility. Good correlation was found between the VSMT and energy. A fair relationship between disability, cognitive reserve, and pain was demonstrated. Good correlation was observed between the Tap Fast score and disability, 5STS, FSS, energy, and physical mobility. A fair relationship was found between pain and social isolation. Conclusion It has been shown that cognitive performance in MS is related to disability, functional performance, cognitive reserve, fatigue, and general health.
dc.identifier.doi10.1055/s-0044-1788273
dc.identifier.endpage9
dc.identifier.issn0004-282X
dc.identifier.issn1678-4227
dc.identifier.issue9
dc.identifier.orcid0000-0002-2765-0121
dc.identifier.orcid0000-0001-7413-6371
dc.identifier.orcid0000-0002-5623-8291
dc.identifier.orcid0000-0002-8381-9630
dc.identifier.pmid39187267
dc.identifier.scopus2-s2.0-85202571154
dc.identifier.scopusqualityQ3
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1055/s-0044-1788273
dc.identifier.urihttps://hdl.handle.net/11616/109300
dc.identifier.volume82
dc.identifier.wosWOS:001298559700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAssoc Arquivos Neuro- Psiquiatria
dc.relation.ispartofArquivos De Neuro-Psiquiatria
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectMultiple Sclerosis
dc.subjectCognition
dc.subjectCognitive Reserve
dc.subjectMobile Applications
dc.subjectMuscle Strength
dc.subjectPhysical Functional Performance
dc.titleThe relationship between cognitive function and functional capacity, and cognitive reserve and reaction time in patients with multiple sclerosis
dc.typeArticle

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