Effect of resveratrol in experimental osteoarthritis in rabbits

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridErtem, Kadir/0000-0002-8892-494X
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidElmali, Nurzat/A-1017-2014
dc.authorwosidErtem, Kadir/ABG-9780-2020
dc.contributor.authorElmali, N
dc.contributor.authorEsenkaya, I
dc.contributor.authorHarma, A
dc.contributor.authorErtem, K
dc.contributor.authorTurkoz, Y
dc.contributor.authorMizrak, B
dc.date.accessioned2024-08-04T20:14:56Z
dc.date.available2024-08-04T20:14:56Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Resveratrol (trans-3,4',5-trihydroxystilbene) is a phytoalexin found in high concentration in the skins of grapes and red wines which has been shown to have antiinflammatory, anticancerogen and antioxidant properties. Resveratrol is a potent and specific inhibitor of nuclear factor kappa B ( NF-kappa B). Resveratrol also inhibits COX-2 gene expression and enzyme activity. We aimed to determine the in vivo effects of intra-articular injections of resveratrol on cartilage and synovium in an experimental osteoarthritis (OA) model in rabbits. Methods: As OA model, rabbits underwent unilateral anterior cruciate ligament transection (ACLT). Five weeks after test group was injected with 10 mu Mol/kg resveratrol in dimethylsulphoxide ( DMSO) in the knees once daily for two weeks and as the control group at the same time DMSO was injected into the knees. All rabbits were killed one week after the last injection. Cartilage tissue and synovium were evaluated with a histological scoring system. Results: Histological evaluation of cartilage tissue by H&E staining revealed a significantly reduced average cartilage tissue destruction score of 1.7 in the resveratrol group versus 2.8 in the control group ( p = 0.016). Loss of matrix proteoglycan content in cartilage was also much lower, as determined by safranin O staining. Scores of synovial inflammation didn't show difference between groups ( 1,3 vs 2,2; p = 0.057). Conclusion: A characteristic parameter in arthritis is the progressive loss of articular cartilage. This study suggests that intraarticular injections of resveratrol starting at the onset of disease may protect cartilage against the development of experimentally induced OA.en_US
dc.identifier.doi10.1007/s00011-004-1341-6
dc.identifier.endpage162en_US
dc.identifier.issn1023-3830
dc.identifier.issn1420-908X
dc.identifier.issue4en_US
dc.identifier.pmid15883738en_US
dc.identifier.scopus2-s2.0-23844523482en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage158en_US
dc.identifier.urihttps://doi.org/10.1007/s00011-004-1341-6
dc.identifier.urihttps://hdl.handle.net/11616/94064
dc.identifier.volume54en_US
dc.identifier.wosWOS:000229002100003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Basel Agen_US
dc.relation.ispartofInflammation Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectresveratrolen_US
dc.subjectcartilageen_US
dc.subjectosteoarthritisen_US
dc.subjectNF-kappa Ben_US
dc.subjectCOX-2en_US
dc.titleEffect of resveratrol in experimental osteoarthritis in rabbitsen_US
dc.typeArticleen_US

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