Liver pathology and cell proliferation after calcineurin inhibitors and anti proliferative drugs following partial hepatectomy in rats

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dc.authoridYilmaz, Sezai/0000-0002-8044-0297;
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidtürkmen, emine/GXH-9319-2022
dc.contributor.authorKirimlioglu, H
dc.contributor.authorKirimlioglu, V
dc.contributor.authorYilmaz, S
dc.contributor.authorCoban, S
dc.contributor.authorTurkmen, E
dc.contributor.authorAra, C
dc.date.accessioned2024-08-04T20:15:21Z
dc.date.available2024-08-04T20:15:21Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description8th Meeting of the Turkish-Transplantation-Society -- JUN 22-24, 2005 -- Ankara, TURKEYen_US
dc.description.abstractImmunosuppressants are the cornerstones of treatment after solid organ transplantation. This study investigated the pathology and cell proliferation following partial hepatectomy (PH) in rats undergoing immunosuppressive treatment. After I day, all rats were subjected to 70% PH. Groups A and B (n = 10) received calcineurin inhibitors subcutaneously: either FK506 or cyclosporine (CyA). Groups C and D (n = 10) received antiproliferative drugs: either mycophenolate mofetil (MMF) or sirolimus (SRL) by gavage. A control group (n = 5) received 1 mL of tap water daily. On postoperative day 2, all rats were sacrificed to obtain liver tissue for pathologic examination. Using immunohistochemistry we separately examined the hepatectomy surface and the liver parenchyma. In the parenchyma, the Ki-67 indices were higher in the CyA and FK506 groups and lower in the SRL and MMF groups compared with controls (P < .01). CyA had the highest and MMF the lowest values. On the hepatectomy surface, Ki-67 indices and TGF-alpha expressions were higher in the CyA group and lower in the SRL and MMF groups compared with the control group (P < .01). Slightly higher values in the FK506 group were not significantly different compared with the control group (P > .05). All groups other than FK506 showed prominent cholangiolar epithelial phenotypes compared with the control group. In the CyA and SRL groups, the number of cholangiolar cells was higher (P < .01), and in the MMF group lower than in the control group (P < .01). Among all groups, SRL had the highest values.en_US
dc.description.sponsorshipTurkish Transplantat Socen_US
dc.identifier.doi10.1016/j.transproceed.2005.12.097
dc.identifier.endpage626en_US
dc.identifier.issn0041-1345
dc.identifier.issue2en_US
dc.identifier.pmid16549191en_US
dc.identifier.scopus2-s2.0-33645054829en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage622en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2005.12.097
dc.identifier.urihttps://hdl.handle.net/11616/94319
dc.identifier.volume38en_US
dc.identifier.wosWOS:000236440100075en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImmunosuppressive Drugsen_US
dc.subjectRegenerationen_US
dc.subjectRapamycinen_US
dc.subjectCyclosporineen_US
dc.subjectAugmentationen_US
dc.subjectFk-506en_US
dc.subjectTargeten_US
dc.subjectOnseten_US
dc.titleLiver pathology and cell proliferation after calcineurin inhibitors and anti proliferative drugs following partial hepatectomy in ratsen_US
dc.typeConference Objecten_US

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