In vivo evidence suggesting a role for purine-catabolizing enzymes in the pathogenesis of cisplatin-induced nephrotoxicity in rats and effect of erdosteine against this toxicity

Basit Öğe Kaydı
dc.authoridOZYURT, Huseyin/0000-0003-2327-4082;
dc.authorwosidOZYURT, Huseyin/N-4351-2015
dc.authorwosidulu, ramazan/V-9751-2018
dc.contributor.authorSögüt, S
dc.contributor.authorKotuk, M
dc.contributor.authorYilmaz, HR
dc.contributor.authorUlu, R
dc.contributor.authorÖzyurt, H
dc.contributor.authorYildirim, Z
dc.date.accessioned2024-08-04T20:14:43Z
dc.date.available2024-08-04T20:14:43Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this experimental study was to investigate the possible role of adenosine deaminase (AD) and xanthine oxidase (XO) in the pathogenesis of cisplatin-induced nephrotoxicity and the effect of erdosteine in decreasing the toxicity. The intraperitoneal injection of cisplatin (7m kg(-1) body weight) induced a significant increase in plasma creatinine level and blood urea nitrogen (BUN), and plasma and damaged renal tissue activities of AD and XO in rats. Co-treatment with erdosteine (10 mg kg(-1) day(-1)) attenuated the increase in the plasma creatinine and BUN levels, and significantly prevented the increase in tissue and plasma AD and XO activities (P < 0.05). The results of this study revealed that XO and AD may play an important role in the pathogenesis of cisplatin-induced nephrotoxicity. The potent free radical scavenger erdosteine may have protective potential in this process and it will become a promising drug in the prevention of this undesired side-effect of cisplatin. but further studies are needed to illuminate the exact protection mechanism of erdosteine against cisptatin-induced nephrotoxicity. Copyright (C) 2004 John Wiley Sons, Ltd.en_US
dc.identifier.doi10.1002/cbf.1069
dc.identifier.endpage162en_US
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue3en_US
dc.identifier.pmid15124180en_US
dc.identifier.scopus2-s2.0-1842567627en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage157en_US
dc.identifier.urihttps://doi.org/10.1002/cbf.1069
dc.identifier.urihttps://hdl.handle.net/11616/93914
dc.identifier.volume22en_US
dc.identifier.wosWOS:000221501300005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biochemistry and Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectxanthine oxidaseen_US
dc.subjectadenosine deaminaseen_US
dc.subjectcisplatinen_US
dc.subjectnephrotoxicityen_US
dc.subjecterdosteineen_US
dc.titleIn vivo evidence suggesting a role for purine-catabolizing enzymes in the pathogenesis of cisplatin-induced nephrotoxicity in rats and effect of erdosteine against this toxicityen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu