Beta-glucan prevents toxic effects of 2,3,7,8-TCDD in terms of oxidative and histopathological damage in heart tissue of rats

Basit Öğe Kaydı
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridCETIN, Asli/0000-0003-3902-3210
dc.authorwosidTaşlıdere, Aslı/ABI-8274-2020
dc.authorwosidbasak, nese/ABH-5495-2020
dc.contributor.authorCiftci, Osman
dc.contributor.authorDuman, Ahmet Sefa
dc.contributor.authorTurkmen, Nese Basak
dc.contributor.authorTaslidere, Asli
dc.date.accessioned2024-08-04T20:45:37Z
dc.date.available2024-08-04T20:45:37Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstract2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant which causes severe toxic effects. Despite there is some suggestion concerning with TCDD induced cardiotoxicity such as formation of free radicals, the main mechanism has not been entirely explained. Beta-glucan is known as strong antioxidant matter and can scavenge free radicals. Therefore this study aimed to investigate the protective effects of beta-glucan against TCDD induced cardiotoxicity in rats. In this study, 2-3 months of age and 190-250 g in weight 32 rats were randomly divided into four equal groups (n=8 for each group). Group 1 was control; Group 2 was TCDD group (2 mu g/kg/week); group 3 was the beta-glucan group(50 mg/kg/day), and group 4 was TCDD and beta-glucan treatment group. The heart samples were taken from rats after 21 days treatment. The results were shown that Despite TCDD exposure visibly caused to increase (p <= 0.001) in TBARS levels, It caused a visible decline in the levels of GSH, CAT, GSH-Px, and SOD. However Beta glucan significantly increased GSH, CAT, GSH-Px, SOD levels and decreased generation of TBARS. Additionally, our histopathological observations were in agreement with the biochemical results. In conclusion, Beta-glucan treatment exhibited protective activity on TCDD induced cardiotoxicity.en_US
dc.identifier.doi10.1590/s2175-97902018000317674
dc.identifier.issn1984-8250
dc.identifier.issn2175-9790
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85059273272en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1590/s2175-97902018000317674
dc.identifier.urihttps://hdl.handle.net/11616/98592
dc.identifier.volume54en_US
dc.identifier.wosWOS:000452199300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Sao Paulo, Conjunto Quimicasen_US
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBeta-glucan/protective effectsen_US
dc.subject2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)en_US
dc.subjectCardiotoxicityen_US
dc.subjectRatsen_US
dc.titleBeta-glucan prevents toxic effects of 2,3,7,8-TCDD in terms of oxidative and histopathological damage in heart tissue of ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu