The protective effect of aminoguanidine on random pattern skin flap survival: An experimental study in rats

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dc.authorscopusid57197103613
dc.authorscopusid7005744078
dc.authorscopusid6602664864
dc.authorscopusid16066587500
dc.authorscopusid6602379395
dc.contributor.authorAydo?an H.
dc.contributor.authorGürlek A.
dc.contributor.authorParlakpinar H.
dc.contributor.authorAydo?an N.
dc.contributor.authorAcet A.
dc.date.accessioned2024-08-04T20:00:54Z
dc.date.available2024-08-04T20:00:54Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Distal flap necrosis resulting from ischemia is a serious problem, and increases the cost of treatment. Reactive oxygen radicals (ROS) play an important role in tissue injury and ischemia, and may lead to partial or complete flap necrosis. Aminoguanidine (AG), a potent antioxidant, prevents ROS formation and lipid peroxidation. Besides, AG inhibits inducible nitric oxide synthase (iNOS) leading to decreased generation of nitric oxide (NO). Material and Methods: Rats were randomly divided into three groups: Control, flap elevated saline group, and AG treated group, A caudally based rectangular flap, 3 x 10-cm was elevated on the back of the rats. Flap viability was evaluated 7 days after the initial operation, measuring necrotic areas and total flap areas by computer-assisted planimetry. Malondialdehyde (MDA), NO, glutathione (GSH), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) levels were measured in flap skin tissue to observe the effects of AG. Results: Rate of flap necrosis and MDA, NO levels were higher in the saline group compared to the control group, while GSH, GSH-Px, and SOD enzyme activities were reduced. AG administration reduced lipid peroxidation, NO generation and increased GSH, GSH-Px, SOD enzyme activities. Furthermore, it significantly reduced the rate of flap necrosis when compared with the saline group. Conclusion: We believe that AG, a potent antioxidant and iNOS inhibitor, has beneficial effects to improve skin flap viability when distal flap necrosis is a potential complication in longer flaps. Copyright © 2007 by Türkiye Klinikleri.en_US
dc.identifier.endpage43en_US
dc.identifier.issn1300-0292
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-34047140341en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage36en_US
dc.identifier.urihttps://hdl.handle.net/11616/91101
dc.identifier.volume27en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAminoguanidineen_US
dc.subjectMalondialdehydeen_US
dc.subjectReactive oxygen speciesen_US
dc.subjectSurgical flapsen_US
dc.titleThe protective effect of aminoguanidine on random pattern skin flap survival: An experimental study in ratsen_US
dc.title.alternativeAmi?noguani?di?ni?n random paternli? ci?lt flebi? yaşayabi?li?rli??i? üzeri?ne etki?si?: siçanlarda deneysel çalişmaen_US
dc.typeArticleen_US

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