The effects of caffeic acid phenethyl ester and melatonin on age-related vascular remodeling and cardiac damage

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.authorwosidERDOĞAN, Ali/ABG-8548-2020
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.contributor.authorEsrefoglu, Mukaddes
dc.contributor.authorGul, Mehmet
dc.contributor.authorAtes, Burhan
dc.contributor.authorErdogan, Ali
dc.date.accessioned2024-08-04T20:35:34Z
dc.date.available2024-08-04T20:35:34Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOxidative stress has been implicated with cardiovascular aging. Most antioxidant intervention studies have involved long-term treatments as a potential means to eliminate age-related oxidative damage in many systems. In the present study, not only light and electron microscopic pictures of the heart and thoracic aorta of young and aged and, caffeic acid phenethyl ester (CAPE) and melatonin and administered aged Sprague Dawley rats, but also antioxidant system status was evaluated. Significantly elevated levels of malondialdehyde (MDA) were observed in the heart and thoracic aorta of aged rats (P < 0.05 and P < 0.001, respectively). Chronic melatonin and CAPE administration significantly reduced the levels of MDA in the heart (P = 0.005 and P = 0.05, respectively) and thoracic aorta (P < 0.001 and P < 0.05, respectively) of aged animals. Additionally, melatonin and CAPE were efficient in stimulating the activities and increasing the levels of the antioxidant enzymes in the heart and aorta. Prominent electron microscopic alterations in cardiac myocytes such as nuclear irregularity, mitochondrial degeneration, myofilament disorganization and disruption, and lipofuscin accumulation were observed in aged rats. The main age-related histologic modifications observed in aorta were irregularity in endothelial cells and their nuclei, divergence of endothelial cells from basement membrane and neighboring cells, and elastic fibril fragmentation and reduction. Melatonin and CAPE obviously reduced these alterations in both heart and aorta of aged rats. Taking the results together, we suggest that supplemental administration of CAPE and melatonin is beneficial in delaying age-related cellular damage in cardiovascular system.en_US
dc.identifier.doi10.1111/j.1472-8206.2010.00876.x
dc.identifier.endpage590en_US
dc.identifier.issn0767-3981
dc.identifier.issn1472-8206
dc.identifier.issue5en_US
dc.identifier.pmid20880386en_US
dc.identifier.scopus2-s2.0-80052914771en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage580en_US
dc.identifier.urihttps://doi.org/10.1111/j.1472-8206.2010.00876.x
dc.identifier.urihttps://hdl.handle.net/11616/95442
dc.identifier.volume25en_US
dc.identifier.wosWOS:000294922700004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofFundamental & Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectagingen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectmelatoninen_US
dc.subjectoxidative stressen_US
dc.titleThe effects of caffeic acid phenethyl ester and melatonin on age-related vascular remodeling and cardiac damageen_US
dc.typeArticleen_US

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