Glucagon-like peptide-1 and-2 levels in children with diabetic ketoacidosis.
Küçük Resim Yok
Tarih
2009
Yazarlar
Dergi Başlığı
Dergi ISSN
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Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study was to investigate whether insulin deficiency and increased catabolism may have a role in the regulation of plasma glucagon-like peptide (GLP)-1 and GLP-2 levels in children with diabetic ketoacidosis (DKA) and whether insulin treatment may affect the levels of these polypeptides. Plasma GLP-1 and -2 levels were measured in 24 patients with DKA aged 8 to 14 years before insulin infusion (time 0), when ketonemia and acidosis disappeared (time 1), and when weight gain started (time 2). Eighteen healthy children aged 8 to 14 years constituted the control group. At time 0, mean plasma GLP-1 and GLP-2 levels were significantly elevated in the patients compared with the control group (p<0.05 and p<0.01, respectively). At time 1 when ketonemia and acidosis disappeared, GLP-1 and GLP-2 levels decreased significantly from the initial levels (p<0.05 and p<0.01, respectively). At this time, while GLP-1 level was not different from that of the controls, GLP-2 level was higher than that of the controls (p<0.05). GLP-1 and-2 levels did not show any significant differences between the patients and controls when weight gain started (time 2). Our results show that DKA is associated with increased plasma GLP-1 and -2 concentrations. Effective fluid and insulin treatment resulted in a significant decrease in plasma GLP-1 and -2 levels. This may be due to the negative feedback effect of insulin on the production of these polypeptides.
Açıklama
Anahtar Kelimeler
antidiabetic agent, glucagon like peptide 1, glucagon like peptide 2, insulin, adolescent, article, blood, case control study, child, diabetic ketoacidosis, female, human, insulin dependent diabetes mellitus, male, Adolescent, Case-Control Studies, Child, Diabetes Mellitus, Type 1, Diabetic Ketoacidosis, Female, Glucagon-Like Peptide 1, Glucagon-Like Peptide 2, Humans, Hypoglycemic Agents, Insulin, Male
Kaynak
Journal of clinical research in pediatric endocrinology
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
1
Sayı
3
