Analysis of manganese superoxide dismutase (MnSOD: Ala-9Val) and glutathione peroxidase (GSH-Px: Pro 197 Leu) gene polymorphisms in mood disorders

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dc.authoridOZYURT, Huseyin/0000-0003-2327-4082
dc.authoridKarlıdağ, Rifat/0000-0002-3650-0774
dc.authorwosidkarlıdağ, rıfat/AAB-4255-2021
dc.authorwosidOZYURT, Huseyin/N-4351-2015
dc.authorwosidKarlıdağ, Rifat/AAB-4281-2021
dc.contributor.authorCumurcu, Birgul Elbozan
dc.contributor.authorOzyurt, Huseyin
dc.contributor.authorAtes, Omer
dc.contributor.authorGul, Isil Gogcegoz
dc.contributor.authorDemir, Suleyman
dc.contributor.authorKarlidag, Rifat
dc.date.accessioned2024-08-04T20:37:51Z
dc.date.available2024-08-04T20:37:51Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe investigated the etiopathogenetic role of manganese superoxide dismutase (MnSOD) (Ala-9Val) and glutathione peroxidase (GSH-Px) (Pro 197 Leu) gene polymorphisms in patients diagnosed with major depressive disorder (MDD) and bipolar I disorder (BD). Eighty patients with MDD, 82 patfents with BD (total 162 patients) and 96 healthy controls were enrolled in this study and genotyped using a Real Time-Quantitative Polymer Chain Reaction (RT-qPCR)-based method. The patients with BD and MDD and the controls had a similar distribution of the genotypes and alleles in the Ala-9Val MnSOD gene polymorphism. Comparison of the MDD group and control group regarding the Pro 197 Leu GSH-Px gene polymorphism revealed similar genotype distribution but different allele distribution. The BD group and control group were similar both for genotypes and for alleles when compared regarding the Pro 197 Leu GSH-Px gene polymorphism. The combined analysis (MDD plus BD) also failed to find any association between the Ala-9Val MnSOD and Pro 197 Leu GSH-Px gene polymorphism. Although small statistical power of the current study the significant difference between patients with depression and the control group for the Pro 197 Leu GSH-Px polymorphism indicates that the distribution of these alleles may have a contribution in the physiopathogenesis of depression. One of the limitation of the current study is that the sample size is too small. Understanding of the exact role of Pro 197 Leu GSH-Px polymorphism in the development of depression needs to further studies with more sample size and high statistical power. (C) 2013 Association of Basic Medical Sciences of FB&H. All rights reserveden_US
dc.description.sponsorshipGaziosmanpasa University Research Foundationen_US
dc.description.sponsorshipThis study was supported by a grant the Gaziosmanpasa University Research Foundation.en_US
dc.identifier.endpage113en_US
dc.identifier.issn1512-8601
dc.identifier.issn1840-4812
dc.identifier.issue2en_US
dc.identifier.pmid23725507en_US
dc.identifier.scopus2-s2.0-84883764072en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage109en_US
dc.identifier.urihttps://hdl.handle.net/11616/96200
dc.identifier.volume13en_US
dc.identifier.wosWOS:000330925000008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevoen_US
dc.relation.ispartofBosnian Journal of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbipolar I disorderen_US
dc.subjectmajor depressive disorderen_US
dc.subjectmanganese superoxide dismutaseen_US
dc.subjectglutathione peroxidaseen_US
dc.subjectpolymorphismen_US
dc.titleAnalysis of manganese superoxide dismutase (MnSOD: Ala-9Val) and glutathione peroxidase (GSH-Px: Pro 197 Leu) gene polymorphisms in mood disordersen_US
dc.typeArticleen_US

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