Angiotensin II and angiotensin II receptor 2 levels can predict shock and mortality in septic patients

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dc.authoridbicakcioglu, murat/0000-0001-9101-6857;
dc.authorwosidbicakcioglu, murat/AAA-8149-2022
dc.authorwosidBULUT, Nilüfer/HJH-8128-2023
dc.authorwosidOZER, Ayse B/R-8915-2018
dc.contributor.authorOzer, Ayse B.
dc.contributor.authorBicakcioglu, Murat
dc.contributor.authorBaykan, Seyma
dc.contributor.authorBulut, Nilufer
dc.contributor.authorKalkan, Serkan
dc.contributor.authorDemircan, Selcuk
dc.contributor.authorKorkmaz Disli, Zeliha
dc.date.accessioned2024-08-04T20:53:12Z
dc.date.available2024-08-04T20:53:12Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND: The aim of this study was to evaluate the place of angiotensin II and its receptors in the prognosis of septic patients. METHODS: Patients with sepsis and septic shock were included in the study group. The control group consisted of patients who were followed up in the ICU and had no sepsis/septic shock. Plasma angiotensin II, angiotensin receptor-1 and 2 (AT-1, AT-2) levels were evaluated first and third days.RESULTS: Angiotensin II levels were significantly lower in the septic shock and non-survivor. AT-1 levels were lower in all septic patients on the first day compared to the control. While AT-1 levels on the third day decreased in the septic shock group, it increased in the sepsis group. AT-2 levels were significantly higher in sepsis, and lower in septic shock compared to controls on the first day. Angiotensin II (95%, 82%) and AT-2 levels (100%, 87%) were observed to have high sensitivity and specificity in demonstrating the presence of shock in septic patients. Angiotensin II and AT-1/AT-2 ratios were observed to have high sensitivity and low specificity in the development of mortality.CONCLUSIONS: In septic patients, angiotensin II, AT-2 and AT-1/AT-2 levels can predict the probability of shock development and mortality. (Cite this article as: Ozer AB, Bicakcioglu M, Baykan S, Bulut N, Kalkan S, Demircan S, et al. Angiotensin II and angio-tensin II receptor 2 levels can predict shock and mortality in septic patients. Minerva Anestesiol 2022;88:1021-9. DOI: 10.23736/S0375-9393.22.16566-1)en_US
dc.description.sponsorshipScientific Research Project Unit of Inonu Universityen_US
dc.description.sponsorshipThis research was funded by a grant from The Scientific Research Project Unit of Inonu University.en_US
dc.identifier.doi10.23736/S0375-9393.22.16566-1
dc.identifier.endpage1029en_US
dc.identifier.issn0375-9393
dc.identifier.issn1827-1596
dc.identifier.issue12en_US
dc.identifier.pmid35708041en_US
dc.identifier.scopus2-s2.0-85143088685en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1021en_US
dc.identifier.urihttps://doi.org/10.23736/S0375-9393.22.16566-1
dc.identifier.urihttps://hdl.handle.net/11616/101028
dc.identifier.volume88en_US
dc.identifier.wosWOS:000897580500006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEdizioni Minerva Medicaen_US
dc.relation.ispartofMinerva Anestesiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiotensin IIen_US
dc.subjectReceptorsen_US
dc.subjectangiotensinen_US
dc.subjectSepsisen_US
dc.subjectShocken_US
dc.subjectsepticen_US
dc.subjectMortalityen_US
dc.titleAngiotensin II and angiotensin II receptor 2 levels can predict shock and mortality in septic patientsen_US
dc.typeArticleen_US

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