Examination of the effect of melatonin use before hysterosalpingography on ovarian follicle reserve in rats

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dc.authoridAKPOLAT, Nusret/0000-0002-9138-2117
dc.authorwosidSapmaz, Tansel/JMQ-6337-2023
dc.authorwosidKocamaz, Derya/U-9743-2018
dc.authorwosidAKPOLAT, Nusret/ABF-6986-2020
dc.contributor.authorYilmaz, E. S.
dc.contributor.authorSapmaz, T.
dc.contributor.authorKazgan, H.
dc.contributor.authorYildiz, S. Menziletoglu
dc.contributor.authorKocamaz, D.
dc.contributor.authorAkpolat, N.
dc.contributor.authorSapmaz, E.
dc.date.accessioned2024-08-04T20:45:23Z
dc.date.available2024-08-04T20:45:23Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To examine the effects of lipiodol, melatonin, and radiation used during hysterosalpingography (HSG) on rat ovarian follicle reserve. Materials and Methods: A total of 50 Wistar rats with regular estrous cycles were randomly divided into five groups. Group 1 was the control group. The other groups, X-ray was applied (G2), 0.1 ml lipiodol was applied to each uterine horn (G3), 20 mg/kg intraperitoneal melatonin application was followed by 0.1 ml lipiodol administration to each uterine horn after 15 minutes (G4), 20 mg/kg melatonin was administered to ligamentum suspensorium ovarii, followed by 0.1 ml lipiodol application to each uterine horn after 15 minutes (G5), respectively. The rats in G2, G3, G4, and G5 were exposed three times to whole body radiation. Then, all rats were re-opened and left oophorectomy was performed. Left ovarian samples were fixed in formaldehyde. Primordial, primary, secondary, and tertiary follicles were counted in the preparations, and all were added to calculate the ovarian follicle reserve. Results: Primordial, primary, and ovarian follicle reserves were found significantly lower in G2, in comparison to other groups. Atretic follicle values were significantly higher in G2 compared to G3, and in G3 compared to the other groups. Regression of angiogenesis within corpus luteum was found significantly lower in G2, compared to G3, and in G3 compared to other groups. All values in G1, G4, and G5 were similar. Conclusion: Use of lipiodol and melatonin during HSG procedure prevents the negative effects of radiation on ovarian follicle reserve.en_US
dc.identifier.doi10.12891/ceog4236.2018
dc.identifier.endpage574en_US
dc.identifier.issn0390-6663
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85052550608en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage570en_US
dc.identifier.urihttps://doi.org/10.12891/ceog4236.2018
dc.identifier.urihttps://hdl.handle.net/11616/98447
dc.identifier.volume45en_US
dc.identifier.wosWOS:000444384300018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisher7847050 Canada Incen_US
dc.relation.ispartofClinical and Experimental Obstetrics & Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHSGen_US
dc.subjectLipiodolen_US
dc.subjectMelatoninen_US
dc.subjectOvarian follicle reserveen_US
dc.subjectRaten_US
dc.titleExamination of the effect of melatonin use before hysterosalpingography on ovarian follicle reserve in ratsen_US
dc.typeArticleen_US

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