Alkylation of morpholine and prolidine by phthalimide substituted Ru(II)- NHC catalysts

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dc.authoridAKKOÇ, Mitat/0000-0001-8641-8958
dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authorwosidAKKOÇ, Mitat/AAJ-5780-2020
dc.contributor.authorAkkoc, Mitat
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorOzdemir, Ismail
dc.date.accessioned2024-08-04T20:56:08Z
dc.date.available2024-08-04T20:56:08Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, a series of benzimidazolium salts and silver-benimidazol-2-ylidene complexes were synthesized. The obtained silver complexes were converted into Ru(II)- benimidazol-2-ylidene complex using the transmetallation method. After elucidating the structures of these Ru(II)-NHC compounds, the synthesized ruthenium complexes were used in the alkylation reaction of cyclic amines to synthesize valuable derivatives such as pyrrolidine and morpholine. Pyrrolidine derivatives are extensively studied for their antimicrobial, antiviral, antifungal, anticancer, anti-inflammatory, anticonvulsant, cholinesterase inhibition, and carbonic anhydrase inhibition properties. Morpholine derivatives are particularly studied in the context of central nervous system (CNS) diseases. The yield of the catalytic products obtained was determined by GC. High selectivity and yield were achieved in the alkylation reactions of heterocyclic structures.en_US
dc.description.sponsorshipInonu University [FBG-2023-3273]en_US
dc.description.sponsorshipThis work was financially supported by the Inonu University Research Fund (FBG-2023-3273).en_US
dc.identifier.doi10.1016/j.poly.2024.117109
dc.identifier.issn0277-5387
dc.identifier.issn1873-3719
dc.identifier.scopus2-s2.0-85196938859en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.poly.2024.117109
dc.identifier.urihttps://hdl.handle.net/11616/102083
dc.identifier.volume261en_US
dc.identifier.wosWOS:001261664100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPolyhedronen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN -Heterocyclic carbeneen_US
dc.subjectRuthenium(II)en_US
dc.subjectHeterocyclic aminen_US
dc.subjectCyclic amineen_US
dc.subjectAlkylationen_US
dc.titleAlkylation of morpholine and prolidine by phthalimide substituted Ru(II)- NHC catalystsen_US
dc.typeArticleen_US

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