Expression of sirtuins 1 in placenta, umbilical cord, and maternal serum of patients diagnosed with placenta accreta spectrum

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dc.contributor.authorTaskin, Irmak Icen
dc.contributor.authorGurbuz, Sevim
dc.contributor.authorIcen, Mehmet Sait
dc.contributor.authorDerin, Dilek Cam
dc.contributor.authorFindik, Fatih Mehmet
dc.contributor.authorDeveci, Engin
dc.date.accessioned2026-04-04T13:32:58Z
dc.date.available2026-04-04T13:32:58Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractOBJECTIVE: Placenta accreta spectrum (PAS) is defined as the attachment of the placenta to the uterine wall in varying degrees. However, the studies have explored that the underlying molecular mechanisms of the PAS are very limited. Sirtuins 1 (SIRT1) is associated with placental development by controlling trophoblast cell invasion and remodeling of spiral arteries. We aimed to determine the expression level of SIRT1 in placentas, and maternal and umbilical cord serum of patients with PAS. METHODS: In total, 30 individuals in control, 20 patients in the placenta previa group, and 30 patients in the PAS group were included in this study. The expression levels of SIRT1 in the placentas were determined by Western blot and immunohistochemistry. Serum levels of SIRT1 in maternal and umbilical cord blood were determined by ELISA. RESULTS: SIRT1 was significantly lower in placentas of the PAS. However, maternal and umbilical cord serum samples were not significantly different between groups. CONCLUSION: SIRT1 may play an important role in the pathogenesis of the PAS.
dc.description.sponsorshipResearch Council of Turkey [220S416]; Inonu University Scientific Research Projects Unit [TYL-2021-2348]
dc.description.sponsorshipResearch Council of Turkey (grant number: 220S416) and the Inonu University Scientific Research Projects Unit (grant number: TYL-2021-2348) . Received on February 27, 2024. Accepted on May 06, 2024.
dc.identifier.doi10.1590/1806-9282.20240314
dc.identifier.issn0104-4230
dc.identifier.issn1806-9282
dc.identifier.issue8
dc.identifier.orcid0000-0001-5617-4067
dc.identifier.orcid0000-0001-9196-8399
dc.identifier.orcid0000-0002-1612-0563
dc.identifier.orcid0000-0001-9142-6127
dc.identifier.pmid39166679
dc.identifier.scopus2-s2.0-85202004078
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1590/1806-9282.20240314
dc.identifier.urihttps://hdl.handle.net/11616/108846
dc.identifier.volume70
dc.identifier.wosWOS:001293484200005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAssoc Medica Brasileira
dc.relation.ispartofRevista Da Associacao Medica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectUmbilical cord
dc.subjectSerum
dc.subjectPlacenta accreta
dc.subjectSirtuin 1
dc.titleExpression of sirtuins 1 in placenta, umbilical cord, and maternal serum of patients diagnosed with placenta accreta spectrum
dc.typeArticle

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