The effects of Teucrium polium on ionizing radiation-induced intestinal damage in rats

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dc.authoridsahin, nurhan/0000-0001-9487-1154
dc.authoridHarputluoglu, Muhsin Murat Muhip/0000-0002-9415-147X
dc.authoridSelçuk, Engin Burak/0000-0001-8484-0223
dc.authoridAYDIN, Nasuhi/0000-0003-3145-2432
dc.authorwosidsahin, nurhan/ABF-8007-2020
dc.authorwosidBARLAZ US, Songul/AEC-2551-2022
dc.authorwosidHarputluoglu, Muhsin Murat Muhip/ABI-3094-2020
dc.authorwosidAydin, Nasuhi E/B-6536-2012
dc.authorwosidSelçuk, Engin Burak/AAR-7556-2020
dc.authorwosidAYDIN, Nasuhi Engin/L-1607-2019
dc.authorwosidSahin, Nurhan/D-5626-2009
dc.contributor.authorDemirel, U.
dc.contributor.authorHarputluoglu, M. M. M.
dc.contributor.authorUs, S. B.
dc.contributor.authorKaya, E.
dc.contributor.authorSahin, N.
dc.contributor.authorAydin, N. E.
dc.contributor.authorGursoy, S.
dc.date.accessioned2024-08-04T20:35:47Z
dc.date.available2024-08-04T20:35:47Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and study aims : Oxidative stress plays an important role in development of intestinal injury after abdomino-pelvic radiation therapy. Teucrium poliuin (TP) is a medicinal plant which has antioxidant and anti-inflammatory properties. The aim of this study was to investigate the effect of TP on radiation-induced intestinal oxidative damage in rats. Materials and methods : Group 1 (n = 8), the control group; Group 2 (n = 8), the RAD (radiation) group in which each rat received a single whole-body 800 cGy radiation performed with a LINAC; Group 3 (n = 8), the RAD + TP group in which rats were exposed to radiation as in Group 2, followed by intragastric administration of 0.5 g/kg/daily TP extract for 7 consecutive days; and Group 4 (n = 8), the TP group, rats received only intragastric TP for 7 days. Results : Radiation led to intestinal damage, which was accompanied by an increase in intestinal thiobarbituric-acid-reactive substances (TBARS) and myeloperoxidase (MPO) levels, and a decrease in reduced glutathione (GSH) levels. Although TP significantly decreased intestinal MPO levels and inflammation scores, it neither reverted intestinal TBARS and GSH levels nor ameliorated other histological parameters of the disease. Conclusions : Our results suggest that TP reduces inflammation but does not ameliorate the increased oxidative stress conditions in radiation-induced intestinal damage in rats. (Acta gastroenterol. belg., 2011, 74, 491-496).en_US
dc.identifier.endpage496en_US
dc.identifier.issn1784-3227
dc.identifier.issue4en_US
dc.identifier.pmid22319957en_US
dc.identifier.scopus2-s2.0-84858020672en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage491en_US
dc.identifier.urihttps://hdl.handle.net/11616/95594
dc.identifier.volume74en_US
dc.identifier.wosWOS:000299665500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUniv Catholique Louvain-Uclen_US
dc.relation.ispartofActa Gastro-Enterologica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTeucrium poliumen_US
dc.subjectradiationen_US
dc.subjectintestineen_US
dc.subjectoxidative stressen_US
dc.subjectinflammationen_US
dc.titleThe effects of Teucrium polium on ionizing radiation-induced intestinal damage in ratsen_US
dc.typeArticleen_US

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