Investigation of therapeutic effects in the wound healing of chitosan/pGM-CSF complexes

Basit Öğe Kaydı
dc.authoridŞALVA, EMINE/0000-0002-1159-5850
dc.authoridAlan, Saadet/0000-0003-2329-151X
dc.authorwosidŞALVA, EMINE/CAH-3062-2022
dc.authorwosidAlan, Saadet/ABH-4282-2020
dc.contributor.authorSalva, Emine
dc.contributor.authorAlan, Saadet
dc.contributor.authorKarakoyun, Berna
dc.contributor.authorCakalagaoglu, Fulya
dc.contributor.authorOzbas, Suna
dc.contributor.authorAkbuga, Julide
dc.date.accessioned2024-08-04T20:52:08Z
dc.date.available2024-08-04T20:52:08Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractGranulocyte macrophage colony-stimulating factor (GM-CSF) has been shown to promote the growth, proliferation, and migration of endothelial and keratinocyte cells. Chitosan has been widely used as a biopolymer in wound-healing studies. The aim of this study was to investigate the in vitro proliferative effects of chitosan/pGM-CSF complexes as well as the therapeutic role of the complexes in an in vivo rat wound model. The effect of complexes on cell proliferation and migration was examined. Wounds were made in Wistar-albino rats, and examined histopathologically. The cell proliferation and migration were increased weight ratio- and time-dependently in HaCaT and NIH-3T3 cell lines. Wound healing was significantly accelerated in rats treated with the complexes. These results showed that the delivery of pGM-CSF using chitosan complexes could play an accelerating role in the cell proliferation, migration, and wound-healing process.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [SBAGHD-155, 106S232]en_US
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkey (SBAGHD-155, 106S232).en_US
dc.identifier.doi10.1590/s2175-97902022e19668
dc.identifier.issn1984-8250
dc.identifier.issn2175-9790
dc.identifier.scopus2-s2.0-85134212710en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1590/s2175-97902022e19668
dc.identifier.urihttps://hdl.handle.net/11616/100782
dc.identifier.volume58en_US
dc.identifier.wosWOS:000826298400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Sao Paulo, Conjunto Quimicasen_US
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectWound healingen_US
dc.subjectChitosanen_US
dc.subjectpGM-CSFen_US
dc.subjectComplexesen_US
dc.titleInvestigation of therapeutic effects in the wound healing of chitosan/pGM-CSF complexesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu