Beneficial effects of dexpanthenol on mesenteric ischemia and reperfusion injury in experimental rat model

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dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridTANBEK, Kevser/0000-0003-2099-2273
dc.authoridCagin, Yasir Furkan/0000-0002-2538-857X
dc.authoridTağluk, M. Emin/0000-0001-7789-6376
dc.authoridYildiz, Azibe/0000-0001-5686-7867
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidTANBEK, Kevser/ITR-9264-2023
dc.authorwosidCagin, Yasir Furkan/ABI-2709-2020
dc.authorwosidTağluk, M. Emin/ABH-1005-2020
dc.authorwosidYildiz, Azibe/ABI-7998-2020
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.contributor.authorCagin, Yasir Furkan
dc.contributor.authorAtayan, Yahya
dc.contributor.authorSahin, Nurhan
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorPolat, Alaadin
dc.contributor.authorVardi, Nigar
dc.contributor.authorTagluk, Mehmet Emin
dc.date.accessioned2024-08-04T20:41:28Z
dc.date.available2024-08-04T20:41:28Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and aim It has been reported that intestinal ischemia-reperfusion (I/R) injury results from oxidative stress caused by increased reactive oxygen species. Dexpanthenol (Dxp) is an alcohol analogue with epitelization, anti-inflammatory, antioxidant, and increasing peristalsis activities. In the present study, the aim was to investigate protective and therapeutic effects of Dxp against intestinal I/R injury. Materials and methods Overall, 40 rats were assigned into five groups including one control, one alone Dxp, and three I/R groups (40-min ischemia; followed by 2-h reperfusion). In two I/R groups, Dxp (500mg/kg, i.m.) was given before or during ischemia. The histopathological findings including apoptotic changes, and also tissue and serum biochemical parameters levels, were determined. Oxidative stress and ileum damage were assessed by biochemical and histological examination. In the control (n=8) and alone Dxp (n=8; 500mg/kg, i.m. of Dxp was given at least 30min before recording), groups were incised via laparotomy, and electrical activity was recorded from their intestines. In this experiment, the effect of Dxp on the motility of the intestine was examined by analyzing electrical activity. Results In ileum, oxidant levels were found to be higher, while antioxidant levels were found to be lower in I/R groups when compared with controls. Dxp approximated high levels of oxidants than those in the control group, while it increased antioxidant values compared with I/R groups. Histopathological changes caused by intestinal I/R injury and histological improvements were observed in both groups given Dxp. In the Dxp group, electrical signal activity markedly increased compared with the control group. Conclusions Here, it was seen that Dxp had protective and therapeutic effects on intestinal I/R injury and gastrointestinal system peristaltism.en_US
dc.identifier.doi10.3109/10715762.2015.1126834
dc.identifier.endpage365en_US
dc.identifier.issn1071-5762
dc.identifier.issn1029-2470
dc.identifier.issue3en_US
dc.identifier.pmid26631422en_US
dc.identifier.scopus2-s2.0-84955712681en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage354en_US
dc.identifier.urihttps://doi.org/10.3109/10715762.2015.1126834
dc.identifier.urihttps://hdl.handle.net/11616/97144
dc.identifier.volume50en_US
dc.identifier.wosWOS:000368611500008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofFree Radical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDexpanthenolen_US
dc.subjectischemia-reperfusionen_US
dc.subjectintestinal tissueen_US
dc.subjectoxidative stressen_US
dc.subjectraten_US
dc.titleBeneficial effects of dexpanthenol on mesenteric ischemia and reperfusion injury in experimental rat modelen_US
dc.typeArticleen_US

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