Is cerebral spinal fluid flow associated with body mass index and head circumference in healthy children? A phase contrast magnetic resonance imaging study

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dc.authoridSigirci, Ahmet/0000-0001-9221-0002
dc.authoridKılıç, Betül/0000-0003-0884-2635
dc.authorwosidSigirci, Ahmet/ABG-7387-2020
dc.authorwosidÖztürk, Mehmet/JFJ-3399-2023
dc.authorwosidKılıç, Betül/ABS-2287-2022
dc.contributor.authorDemirtas, Gokhan
dc.contributor.authorSigirci, Ahmet
dc.contributor.authorOzturk, Mehmet
dc.contributor.authorGorkem, Sureyya Burcu
dc.contributor.authorKilic, Betul
dc.contributor.authorGungor, Serdal
dc.date.accessioned2024-08-04T20:47:24Z
dc.date.available2024-08-04T20:47:24Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground The aim of this study was to investigate the relationship between age, gender, body mass index (BMI), and head circumference (HC) and cerebral spinal fluid (CSF) flow dynamics in the pediatric population. The prospective study included a total of 137 participants, 75 boys and 62 girls, ranging in age from 2 to 204 months. Quantitative evaluation of CSF flow was made by using phase contrast magnetic resonance imaging (PC-MRI) in the axial plane at the level of the aqueductus cerebri. Flow dynamics were recorded as peak and mean velocity (cm/s); cranial, caudal, and net volume (ml); and aqueductus cerebri area (mm(2)). Correlation between baseline descriptive parameters, including age, gender, BMI, and HC, and the aforementioned CSF flow dynamics were investigated. Results The net volume was significantly lower in girls (p= 0.002). There was no association between age and aqueduct area, mean velocity, and cranial volume. The peak velocity was remarkably higher in children (p= 0.03), whereas cranial and net volume were found to be lower in infants (p= 0.04 andp= 0.03, respectively). Notably, cases with HC below normal values had lower cranial, caudal, and net volume and aqueductus cerebri area (p= 0.01,p= 0.03,p= 0.03, andp= 0.04, respectively). There was no association between BMI and indicators of CSF flow dynamics in PC-MRI. Conclusion BMI and HC may be associated with CSF flow dynamics in children. A smaller HC is accompanied by a lower forward flow volume, reverse flow volume, net volume, and aqueductal diameter. These points should be remembered during the design of further trials on determinants of CSF flow in children.en_US
dc.identifier.doi10.1186/s43055-020-00227-w
dc.identifier.issn2090-4762
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85086643865en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1186/s43055-020-00227-w
dc.identifier.urihttps://hdl.handle.net/11616/99356
dc.identifier.volume51en_US
dc.identifier.wosWOS:000543067600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEgyptian Journal of Radiology and Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMagnetic resonance angiographyen_US
dc.subjectCerebrospinal fluiden_US
dc.subjectFlowen_US
dc.subjectDynamicsen_US
dc.subjectHead circumferenceen_US
dc.subjectBody mass indexen_US
dc.titleIs cerebral spinal fluid flow associated with body mass index and head circumference in healthy children? A phase contrast magnetic resonance imaging studyen_US
dc.typeArticleen_US

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