Investigation of Lorentz field effects on wound healing: theoretical, computational, and experimental analysis

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dc.contributor.authorGurcan, Aliye
dc.contributor.authorAcikgoz, Merve
dc.contributor.authorTutuk, Rabia
dc.contributor.authorAydin, Elif Feyza
dc.contributor.authorYuksel, Furkan
dc.contributor.authorKorkmaz, Engin
dc.contributor.authorTekin, Cigdem
dc.date.accessioned2026-04-04T13:33:31Z
dc.date.available2026-04-04T13:33:31Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractObjective. This study introduces a novel non-invasive wound healing method that generates Lorentz fields (LFs) in the wound area using ultrasonic transducers under a static magnetic field, enabling localized stimulation without direct electrode contact. Approach. Theoretical derivations of the governing equations, supported by numerical simulations, demonstrate the feasibility and potential effectiveness of this technique. The model includes the two-dimensional geometry of the wound, skin layers, gel, a single-element ultrasonic probe, or a 16-element linear phased array (LPA) transducer. The pressure and velocity current density distributions in the wound area were analyzed under three different excitation configurations: (i) excitation using a single-element ultrasonic probe, (ii) beam steering of the LPA transducer at 5 degrees intervals between -30 degrees and +30 degrees at 13 different angles, and (iii) focusing of the LPA transducer at 0 degrees. In each configuration, distinct pressure distributions and velocity current density patterns were obtained in the wound region. In addition, in vivo animal experiments were conducted using the single-element ultrasonic probe to evaluate the biological effects of LF-based stimulation on wound healing. The study included four experimental groups: a static magnetic field (SMF) group, an ultrasound (US) group, a combined LF group, and a control group without any stimulation. Main results. In the single-element probe configuration, the simulated velocity current density reached approximately 4.51 mu Acm-2, corresponding to a pressure of 0.17 MPa. These values remained within the established safety limits while being sufficient to promote wound healing. For the LPA transducer, electronic beam steering enabled a uniform distribution of acoustic pressure and induced current density over a wider wound area. The pressure ranged between +/-(0.118-0.203) MPa, and the corresponding velocity current density varied between +/-(2.33-2.69) mu Acm-2. In the focusing configuration (0 degrees), the maximum pressure in the wound region reached 0.285 MPa, while the peak absolute velocity current density was 6.72 mu Acm-2, both remaining within safe limits. Animal experiments were conducted for 14 d, with each group receiving a 5 min daily treatment. The Lorentz-field group exhibited the fastest wound closure, followed by the US and magnetic-field groups, whereas the control group showed the least improvement. Significance. The proposed method offers an innovative and safe alternative for accelerating wound healing by combining US and SMFs to generate Lorentz-induced current densities in the wound, providing localized and non-invasive therapeutic stimulation.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [122E150]
dc.description.sponsorshipThis work is supported by The Scientific and Technological Research Council of Turkey (TUBITAK) project number 122E150.
dc.identifier.doi10.1088/1361-6560/ae3b95
dc.identifier.issn0031-9155
dc.identifier.issn1361-6560
dc.identifier.issue3
dc.identifier.orcid0000-0002-1647-402X
dc.identifier.pmid41564552
dc.identifier.scopus2-s2.0-105029494949
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1088/1361-6560/ae3b95
dc.identifier.urihttps://hdl.handle.net/11616/109211
dc.identifier.volume71
dc.identifier.wosWOS:001683696000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherIop Publishing Ltd
dc.relation.ispartofPhysics in Medicine and Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectwound healing
dc.subjectLorentz fields
dc.subjectlinear phased array ultrasonic transducer
dc.subjectstatic magnetic field
dc.subjectultrasound
dc.titleInvestigation of Lorentz field effects on wound healing: theoretical, computational, and experimental analysis
dc.typeArticle

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