Bilateral Acute Depigmentation of the Iris: Report of 26 New Cases and Four-year Follow-up of Two Patients

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dc.authorscopusid6602084747
dc.authorscopusid6506646723
dc.authorscopusid55980632200
dc.authorscopusid7004447495
dc.authorscopusid26636196600
dc.authorscopusid55987553900
dc.authorscopusid7007130341
dc.contributor.authorTugal-Tutkun I.
dc.contributor.authorAraz B.
dc.contributor.authorTaskapili M.
dc.contributor.authorAkova Y.A.
dc.contributor.authorYalniz-Akkaya Z.
dc.contributor.authorBerker N.
dc.contributor.authorEmre S.
dc.date.accessioned2024-08-04T19:59:16Z
dc.date.available2024-08-04T19:59:16Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To report new cases of bilateral acute depigmentation of the iris (BADI), a recently described clinical entity, and to report the 4-year follow-up of 2 patients that was published previously. Design: A retrospective case series. Participants: Twenty-six Turkish patients who were diagnosed with BADI between 2006 and 2008 and 2 patients who were reported previously. Methods: We reviewed the patients' charts and clinical photographs. Observation procedures included clinical examination, anterior segment color photography, laser flare photometry, and pupillometry. We performed an anterior chamber tap in 2 patients for polymerase chain reaction (PCR) to demonstrate the DNA of herpes simplex virus (HSV), varicella zoster virus (VZV), and cytomegalovirus (CMV) in the aqueous samples. Main Outcome Measures: Demographic features, presenting symptoms, laboratory findings, changes in iris stromal pigment and architecture, and time to resolution of pigment dispersion in the anterior chamber. Results: Nineteen patients were female, and 7 patients were male. Mean age was 32.3±8.6 years. All had bilateral involvement. Twenty patients (76.9%) presented with photophobia and red eyes, and 4 patients (15.4%) presented with a recent change in eye color. Ten patients (38.5%) had flu-like symptoms preceding the onset of ocular symptoms. Diagnostic laboratory workup, viral serology, and PCR analysis of the aqueous humor were unrewarding. Diffuse depigmentation of the iris stroma from the collarette to the iris root was seen in 16 patients, and geographic areas of depigmentation were seen in 10 patients. There was heavy pigment deposition in the trabecular meshwork in all patients. Anterior chamber flare was elevated in eyes with circulating pigment. The pupil was not affected. Twenty patients received topical corticosteroids. Pigment dispersion resolved in 1 to 16 weeks (median, 9 weeks). The intraocular pressure was elevated in 8 steroid-treated eyes but was controlled with antiglaucomatous medications. In 2 patients reported previously, the depigmented iris stroma became repigmented after 4 years. Conclusions: Patients with BADI present with bilateral, symmetrical, nontransilluminating depigmentation of the iris stroma and pigment discharge into the anterior chamber. Young female persons are more commonly affected. The cause remains unknown. After 4 years, the ocular findings in 2 patients normalized. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. © 2009 American Academy of Ophthalmology.en_US
dc.identifier.doi10.1016/j.ophtha.2009.02.019
dc.identifier.endpage1557.e1en_US
dc.identifier.issn0161-6420
dc.identifier.issue8en_US
dc.identifier.pmid19545903en_US
dc.identifier.scopus2-s2.0-67949095823en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1552en_US
dc.identifier.urihttps://doi.org/10.1016/j.ophtha.2009.02.019
dc.identifier.urihttps://hdl.handle.net/11616/90516
dc.identifier.volume116en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofOphthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantiglaucoma agenten_US
dc.subjectcorticosteroiden_US
dc.subjectpigmenten_US
dc.subjectvirus DNAen_US
dc.subjectacute diseaseen_US
dc.subjectadulten_US
dc.subjectanterior eye chamberen_US
dc.subjectaqueous humoren_US
dc.subjectarticleen_US
dc.subjectclinical articleen_US
dc.subjectclinical examinationen_US
dc.subjectCytomegalovirusen_US
dc.subjectdemographyen_US
dc.subjectdepigmentationen_US
dc.subjecteye coloren_US
dc.subjectfemaleen_US
dc.subjectflu like syndromeen_US
dc.subjectfollow upen_US
dc.subjectHerpes simplex virusen_US
dc.subjecthumanen_US
dc.subjectintraocular hypertensionen_US
dc.subjectirisen_US
dc.subjectmaleen_US
dc.subjectnonhumanen_US
dc.subjectphotographyen_US
dc.subjectphotometryen_US
dc.subjectphotophobiaen_US
dc.subjectpigmentationen_US
dc.subjectpolymerase chain reactionen_US
dc.subjectpriority journalen_US
dc.subjectpupilen_US
dc.subjectpupillometryen_US
dc.subjectretrospective studyen_US
dc.subjecttrabecular meshworken_US
dc.subjectTurkey (republic)en_US
dc.subjectVaricella zoster virusen_US
dc.subjectvirus examinationen_US
dc.titleBilateral Acute Depigmentation of the Iris: Report of 26 New Cases and Four-year Follow-up of Two Patientsen_US
dc.typeArticleen_US

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