Pediatric Hepatocellular Carcinoma

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dc.authoridVarol, İlknur fatma/0000-0001-5212-218X
dc.authorwosidVarol, İlknur fatma/ABH-6387-2020
dc.contributor.authorVarol, Fatma Ilknur
dc.date.accessioned2024-08-04T20:48:53Z
dc.date.available2024-08-04T20:48:53Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose Pediatric hepatocellular carcinoma is rarely seen in childhood. It constitutes approximately 1% of childhood solid organ malignancies. Pediatric hepatocellular carcinoma is the second most common malignant liver tumor after hepatoblastoma in children. In this review, we aimed to review the diagnosis and treatment of pediatric hepatocellular carcinoma in the light of the latest literature. Methods We reviewed the literature in terms of the diagnosis and treatment of pediatric hepatocellular carcinoma. Results Hepatocellular carcinoma (HCC) and hepatoblastoma constitute 0.5-1.5% of all childhood malignant tumors. HCC is responsible for 27% of all liver tumors and 4% of all pediatric liver transplantations. While 99.6% of HCC is seen in adults, only 0.4% of it is seen in pediatric patients. Etiological predisposition and biological behavior are different from adults. In a child with cirrhosis or liver disease, HCC should be suspected in the presence of a high level of AFP and an abnormal nodule on ultrasonography. Hepatoblastoma should be considered first in the differential diagnosis. Conclusion Treatment of pediatric HCC is challenging. Complete surgical resection is essential for the cure. To this end, different neoadjuvant chemotherapy protocols have been designed to convert non-resectable tumors into resectable tumors. For tumors that cannot be resected, liver transplantation for each patient with childhood HCC should be decided individually.en_US
dc.identifier.doi10.1007/s12029-020-00494-w
dc.identifier.endpage1175en_US
dc.identifier.issn1941-6628
dc.identifier.issn1941-6636
dc.identifier.issue4en_US
dc.identifier.pmid32856229en_US
dc.identifier.scopus2-s2.0-85089919948en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1169en_US
dc.identifier.urihttps://doi.org/10.1007/s12029-020-00494-w
dc.identifier.urihttps://hdl.handle.net/11616/99498
dc.identifier.volume51en_US
dc.identifier.wosWOS:000565037300002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Gastrointestinal Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPediatricen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectHepatoblastomaen_US
dc.titlePediatric Hepatocellular Carcinomaen_US
dc.typeReview Articleen_US

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