The protective effects of capsaicin on oxidative damage-induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

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dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridDOGAN, MUHAMMED FATIH/0000-0003-4628-2771
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.contributor.authorDogan, Muhammed Fatih
dc.contributor.authorBasak Turkmen, Nese
dc.contributor.authorTaslidere, Asli
dc.contributor.authorSahin, Yasemin
dc.contributor.authorCiftci, Osman
dc.date.accessioned2024-08-04T20:50:27Z
dc.date.available2024-08-04T20:50:27Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe present study aimed to investigate the protective role of capsaicin in a rat model of 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD)-induced toxicity. Exposure to TCDD which is an environmental toxicant causes severe toxic effects in the animal and human tissues. Therefore, the potential protective effect of capsaicin in TCDD-induced organ damage was investigated in rats by measuring thiobarbituric acid reactive substances (TBARS) level, superoxide dismutase (SOD) activity, and glutathione (GSH) level in the heart, liver, and kidney tissues for oxidant/antioxidant balance. Thirty-two healthy adults (250-300 g weight and 3-4 months old) male Wistar albino rats were randomly distributed into four equal groups (n = 8): Control, CAP, TCDD, TCDD + CAP. A dose of 2 mu g/kg TCDD or a dose of 25 mg/kg capsaicin were dissolved in corn oil and orally administered to the rats for 30 days. The results indicated that TCDD-induced oxidative stress by increasing the level of TBARS and by decreasing the levels of GSH, and SOD activity in the tissues of rats. However, capsaicin treatment was significantly decreased TBARS levels and was significantly increased GSH level and SOD activity (p < 0.05). In addition, capsaicin (25 mg/kg) significantly attenuated TCDD-induced histopathological alteration associated with oxidative stress in the heart, liver, and kidney tissues (p < 0.05). As capsaicin regulates oxidative imbalance and attenuates histopathological alterations in the rat tissues, it may be preventing agents in TCDD toxicity.en_US
dc.identifier.doi10.1080/01480545.2021.1957912
dc.identifier.endpage2470en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue6en_US
dc.identifier.pmid34308744en_US
dc.identifier.scopus2-s2.0-85111414210en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2463en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2021.1957912
dc.identifier.urihttps://hdl.handle.net/11616/100073
dc.identifier.volume45en_US
dc.identifier.wosWOS:000678938200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCapsaicinen_US
dc.subjectTCDDen_US
dc.subjectoxidative damageen_US
dc.subjectdioxinen_US
dc.subjectraten_US
dc.titleThe protective effects of capsaicin on oxidative damage-induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in ratsen_US
dc.typeArticleen_US

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