Resveratrol successfully treats experimental endometriosis through modulation of oxidative stress and lipid peroxidation

Basit Öğe Kaydı
dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authoridAYDIN, Nasuhi/0000-0003-3145-2432
dc.authorwosidSimsek, Yavuz/AAH-9894-2021
dc.authorwosidAYDIN, Nasuhi Engin/L-1607-2019
dc.authorwosidTanbek, Kevser/ABI-1174-2020
dc.authorwosidÖZEROL, ELİF/AAA-6707-2021
dc.authorwosidAYDIN, Nasuhi/O-9043-2016
dc.contributor.authorYavuz, Simsek
dc.contributor.authorAydin, Nasuhi E.
dc.contributor.authorCelik, O.
dc.contributor.authorYilmaz, E.
dc.contributor.authorOzerol, E.
dc.contributor.authorTanbek, K.
dc.date.accessioned2024-08-04T20:39:49Z
dc.date.available2024-08-04T20:39:49Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Aims: The purpose of this study was to investigate the potential therapeutic efficiency of resveratrol in the treatment of experimental endometriosis in rats. Settings and Design: Experimental study was carried out in a University hospital. Materials and Methods: Endometriosis was surgically induced in 24 female rats. Four weeks after this procedure, the viability and dimensions of the endometriosis foci were recorded. Rats were then randomly divided into three groups: (1) Control group (n = 8); (2) low dose (10 mg/kg) resveratrol group (n = 8); (3) high dose (100 mg/kg) resveratrol group (n = 8). At the end of the 7-day treatment, blood samples were taken and laparotomy was performed. The endometrial implants were processed for biochemical, histological and immunohistochemical studies. Statistical Analysis Used: The Kruskal-Wallis H test and one-way ANOVA test were used. Results: Resveratrol-treated rats showed significantly reduced endometriotic implant volumes (P = 0.004). After treatment, a significant and dose-dependent increase in activities of superoxide dismutase and glutathione peroxidase in serum and tissue of the rats in Group 2 and Group 3 was detected. Similarly, serum and tissue malonyl dialdehyde levels and tissue catalase levels were significantly higher in Group 3 than that of control animals. Histological scores and proliferating cell nuclear antigen expression levels were also significantly reduced in Group 2 and Group 3 than that of control group. Conclusion: In a rat endometriosis model, resveratrol showed potential ameliorative effects on endometriotic implants probably due to its potent antioxidative properties.en_US
dc.identifier.doi10.4103/0973-1482.136619
dc.identifier.endpage329en_US
dc.identifier.issn0973-1482
dc.identifier.issn1998-4138
dc.identifier.issue2en_US
dc.identifier.pmid25022386en_US
dc.identifier.scopus2-s2.0-84905690117en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage324en_US
dc.identifier.urihttps://doi.org/10.4103/0973-1482.136619
dc.identifier.urihttps://hdl.handle.net/11616/96532
dc.identifier.volume10en_US
dc.identifier.wosWOS:000348666400019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofJournal of Cancer Research and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndometriosisen_US
dc.subjectoxidative stressen_US
dc.subjectresveratrolen_US
dc.subjecttherapyen_US
dc.titleResveratrol successfully treats experimental endometriosis through modulation of oxidative stress and lipid peroxidationen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu