Protective effect of sitagliptin against renal ischemia reperfusion injury in rats

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dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridBeytur, Ali/0000-0002-7870-3318
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridNuransoy Cengiz, Ayse/0000-0001-9133-8602
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.contributor.authorNuransoy, Ayse
dc.contributor.authorBeytur, Ali
dc.contributor.authorPolat, Alaadin
dc.contributor.authorSamdanci, Emine
dc.contributor.authorSagir, Mustafa
dc.contributor.authorParlakpinar, Hakan
dc.date.accessioned2024-08-04T20:40:17Z
dc.date.available2024-08-04T20:40:17Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study was designed to investigate the protective effects of sitagliptin on renal damage induced by renal ischemia reperfusion (I/R) in rats. For this, rats were randomly divided into four groups (n = 8): (1) sham group, in which the rats only underwent right nephrectomy; (2) right nephrectomy and left kidney ischemia (1 h) and reperfusion (24 h) group (I/R); (3) 5 mg/kg sitagliptin administrated group, per-oral once a day for two weeks; (4) 5 mg/kg sitagliptin administrated group, per-oral once a day for two weeks before left kidney I/R (n = 8). Sitagliptin-treated rats that underwent renal I/R demonstrated significant decrease in the serum urea nitrogen and creatinine and also, lipid peroxidation, total oxidant status and malondialdehyde level in the renal tissue when compared to the renal I/R group. Additionally, reduced glutathione, glutathione peroxidase, superoxide dismutase, catalase and total antioxidative capacity were significantly increased after renal I/R in sitagliptin-treated rats. Our histopathological findings were in accordance with these biochemical results. In sum, in the current study all of our results indicated that sitagliptin treatment ameliorated renal damage induced by renal I/R in rats.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [2209/A-2012]en_US
dc.description.sponsorshipThis study was supported by a grant from The Scientific and Technological Research Council of Turkey (project number: 2209/A-2012, belongs to Ms Nuransoy).en_US
dc.identifier.doi10.3109/0886022X.2015.1010991
dc.identifier.endpage693en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue4en_US
dc.identifier.pmid25703705en_US
dc.identifier.scopus2-s2.0-84930334989en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage687en_US
dc.identifier.urihttps://doi.org/10.3109/0886022X.2015.1010991
dc.identifier.urihttps://hdl.handle.net/11616/96806
dc.identifier.volume37en_US
dc.identifier.wosWOS:000355941500023en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia-reperfusion injuryen_US
dc.subjectkidneyen_US
dc.subjectoxidative stressen_US
dc.subjectraten_US
dc.subjectsitagliptinen_US
dc.titleProtective effect of sitagliptin against renal ischemia reperfusion injury in ratsen_US
dc.typeArticleen_US

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