Novel N-Heterocyclic Carbene Silver(I) Complexes: Synthesis, Structural Characterization, Antimicrobial and Cytotoxicity Potential Studies

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dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authoridMansour, Lamjed/0000-0002-9415-9383
dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.authorwosidMansour, Lamjed/U-3028-2017
dc.authorwosidchakchouk, ahlem/JYP-3425-2024
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.contributor.authorSlimani, Ichraf
dc.contributor.authorChakchouk-Mtibaa, Ahlem
dc.contributor.authorMellouli, Lotfi
dc.contributor.authorMansour, Lamjed
dc.contributor.authorOzdemir, Ismail
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorHamdi, Naceur
dc.date.accessioned2024-08-04T20:48:58Z
dc.date.available2024-08-04T20:48:58Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, a series of unsymmetrical N,N-disubstituted benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) (2a-2j) and their Ag-I complexes. Their structures were characterized by elemental analyses, H-1 and C-13 nuclear magnetic resonance (NMR) and infrared (IR) spectroscopy techniques. Further, both the salts and their silver(I)-NHC complexes have been evaluated for their potential antibacterial properties against a panel of bacterial strains namely, Micrococcus luteus, Listeria monocytogenes, Salmonella Typhimurium, Staphylococcus aureus and Pseudomonas aeruginosa. The results show that silver complexes are effective against Salmonella Typhimurium, Listeria monocytogenes, and Micrococcus luteus with moderate to high activity, and their minimum inhibitory concentrations ranging from 0.0034 to 1.26 mg mL(-1). In addition, the benzimidazoles salts 2a-2j and silver-NHC complexes 3a-3j were screened for their antitumor activity. Complex 3e exhibited the highest antitumor effect with half-maximal inhibitory concentration (IC50) value of 4.2 mu g mL(-1) against MCF-7.en_US
dc.description.sponsorshipKing Saud University, Riyadh, Saudi Arabia [RSP2019/75]en_US
dc.description.sponsorshipThis work was supported by the Research Supporting Project (RSP2019/75), King Saud University, Riyadh, Saudi Arabia.en_US
dc.identifier.doi10.21577/0103-5053.20200107
dc.identifier.endpage2070en_US
dc.identifier.issn0103-5053
dc.identifier.issn1678-4790
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85092118388en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2058en_US
dc.identifier.urihttps://doi.org/10.21577/0103-5053.20200107
dc.identifier.urihttps://hdl.handle.net/11616/99571
dc.identifier.volume31en_US
dc.identifier.wosWOS:000577634100011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSoc Brasileira Quimicaen_US
dc.relation.ispartofJournal of The Brazilian Chemical Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectbenzimidazolium saltsen_US
dc.subjectsilver(I)-NHC complexesen_US
dc.subjectantimicrobial and antitumor activitiesen_US
dc.titleNovel N-Heterocyclic Carbene Silver(I) Complexes: Synthesis, Structural Characterization, Antimicrobial and Cytotoxicity Potential Studiesen_US
dc.typeArticleen_US

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