Cyclin-D1 protooncogen expression in prostate cancer

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dc.authorscopusid24492292800
dc.authorscopusid56108998400
dc.authorscopusid57209851635
dc.authorscopusid7004682700
dc.authorscopusid6507065523
dc.contributor.authorÖzbek E.
dc.contributor.authorMizrak B.
dc.contributor.authorÖzbek M.
dc.contributor.authorBüyükberber S.
dc.contributor.authorDavarci M.
dc.date.accessioned2024-08-04T20:00:41Z
dc.date.available2024-08-04T20:00:41Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCyclin D1, a cell cycle regulator essential for G1 phase progression, has been implicated in the pathogenesis of certain cancers. High levels of these proteins have been reported in certain human malignancies and have been implicated in aberrant cell division and dysregulated tumor growth. In this study, 30 prostate cancer and 25 benign prostate tissues were studied for cyclin D1 expression using an immunohistochemical technique. All of the primary prostate cancer samples revealed regions of moderate to strongly positive nuclear staining for cyclin D1, however there was no nuclear staining in the benign prostate tissue except-weak staining in the stroma. There was a positive correlation between Gleason grade and staining intensity for cyclin D1. The increased expression of cyclin D1 in prostate cancer samples suggests that further studies on the expression of this gene and related genes may be of interest in understanding the pathogenesis of prostate cancer. The positive correlation between Gleason grade and protein expression may be used as a prognostic marker in prostate cancer. Further studies are needed to confirm this suggestion.en_US
dc.identifier.endpage23en_US
dc.identifier.issn1019-3103
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-0034082368en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage15en_US
dc.identifier.urihttps://hdl.handle.net/11616/90929
dc.identifier.volume30en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclin D1en_US
dc.subjectImmunohistochemistryen_US
dc.subjectProstate canceren_US
dc.titleCyclin-D1 protooncogen expression in prostate canceren_US
dc.typeArticleen_US

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