Development of curcumin and docetaxel co-loaded actively targeted PLGA nanoparticles to overcome blood brain barrier

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dc.authoridÖztürk, Süleyman Can/0000-0003-1599-7926
dc.authoridTonbul, Hayrettin/0000-0001-5510-8973
dc.authoridŞahin, Adem/0000-0002-3996-2931
dc.authoridEsendagli, Gunes/0000-0003-4865-2377
dc.authorwosidÖztürk, Süleyman Can/AAA-3552-2022
dc.authorwosidTonbul, Hayrettin/AAR-6961-2020
dc.authorwosidŞahin, Adem/IYT-0077-2023
dc.authorwosidEsendagli, Gunes/Q-5136-2019
dc.contributor.authorSeko, Indrit
dc.contributor.authorTonbul, Hayrettin
dc.contributor.authorTavukcuoglu, Ece
dc.contributor.authorSahin, Adem
dc.contributor.authorAkbas, Sedenay
dc.contributor.authorYanik, Hamdullah
dc.contributor.authorOzturk, Suleyman Can
dc.date.accessioned2024-08-04T20:50:47Z
dc.date.available2024-08-04T20:50:47Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aims of this study were to develop and characterize curcumin (CCM) and docetaxel (DTX) co-loaded poly lactide-co-glycolide (PLGA) nanoparticles (NPs) to overcome blood brain barrier. The cytotoxicity of the obtained curcumin and docetaxel co-loaded polysorbate 80 coated PLGA NPs were studied in U87 glioma cells and bEND.3 endothelial cells. The IC50 values are determined for both cell lines. In vitro release profile of the optimized formulation approximately 27% of DTX was released in the 1. hour and after a steady controlled release the DTX released percentages plateaued after 48. hour. In vitro curcumin release profile had a more controlled released by releasing less than 8% in the 1. hour and plateaued after 48. hour at approximately 78% curcumin released. Polysorbate 80 coated DTX-CCM-PLGA NPs showed no cytotoxicity and had better uptake in bEND.3 cells than uncoated DTX-CCM- PLGA NPs. The combination of CCM and DTX in PLGA nanoparticles showed a significant increased cytotoxic activity compared to CCM and DTX solutions, CCM loaded PLGA NPs and DTX loaded PLGA NPs. Moreover, in vivo biodistribution studies show that polysorbate 80 coating significantly improve brain penetration. Polysorbate 80 coated CCM and DTX loaded PLGA Nanoparticles can be potentially useful in the treatment of glioma by increasing the delivered quantity of drug in the brain through blood-brain barrier.en_US
dc.identifier.doi10.1016/j.jddst.2021.102867
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85117847510en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2021.102867
dc.identifier.urihttps://hdl.handle.net/11616/100280
dc.identifier.volume66en_US
dc.identifier.wosWOS:000719785600006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPLGA Nanoparticlesen_US
dc.subjectBlood brain barrieren_US
dc.subjectCombination drug deliveryen_US
dc.subjectPolysorbate 80en_US
dc.titleDevelopment of curcumin and docetaxel co-loaded actively targeted PLGA nanoparticles to overcome blood brain barrieren_US
dc.typeArticleen_US

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