The effect of intra-abdominal insufflation pressure on liver function in adult patients undergoing laparoscopic cholecystectomy

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dc.authorscopusid8861779700
dc.authorscopusid34569135700
dc.authorscopusid55666804700
dc.authorscopusid7006384185
dc.authorscopusid6602609706
dc.authorscopusid7004486274
dc.contributor.authorÖzpolat Z.
dc.contributor.authorDurmuş M.
dc.contributor.authorToprak H.I.
dc.contributor.authorÖztürk E.
dc.contributor.authorTemel I.
dc.contributor.authorErsoy M.Ö.
dc.date.accessioned2024-08-04T20:02:07Z
dc.date.available2024-08-04T20:02:07Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: The relation between age and the effect of laparoscopic cholecystectomy on hepatocellular integrity has not been evaluated. We aimed to compare conventional liver function tests in two groups of adults of differing age undergoing elective laparoscopic cholecystectomy. Materials and Methods: We studied 43 patients divided into two groups according to age: Group 1, age 18-60 years (n=22) and Group 2, over 65 years (n=21). All patients received general anesthesia. CO2 was used to insufflate the peritoneal cavity, and intraperitoneal pressure was maintained at 10-14 mmHg during cholecystectomy. Reverse Trendelenburg position was maintained after CO2 insufflation. Arterial blood was sampled before the induction of anesthesia, at the end of surgery, and 1, 3, 6 and 24h after surgery for determination serum alanine aminotransferase (ALT) aspartate aminotransferase (AST), alpha-glutathione S-transferase (alpha-GST), and ganima-glutamyl transpeptidase (GGT) concentrations. Results: Baseline values of alpha-GST were within normal limits in both groups. Alpha-GST increased significantly in two groups at the end of surgery and at 1st hour after surgery. The increase of alpha-GST in Group 2 was higher than Group 1. Alpha-GST returned to normal values at 3,6 and 24h after surgery in both groups. Alpha-GST returned to the preoperative value at 24th h after surgery in Group 1 but not in Group 2. Conclusion: We conclude that elderly patients undergoing laparoscopic cholecystectomy have more hepatocellular injury when intraperitoneal pressure is greater than 10 mmHg.en_US
dc.identifier.endpage42en_US
dc.identifier.issn1304-0871
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-14844320733en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage37en_US
dc.identifier.urihttps://hdl.handle.net/11616/91434
dc.identifier.volume33en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurk Anesteziyoloji ve Reanimasyon Dernegi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlpha glutathione S-transferaseen_US
dc.subjectHepatic blood flowen_US
dc.subjectLaparoscopyen_US
dc.titleThe effect of intra-abdominal insufflation pressure on liver function in adult patients undergoing laparoscopic cholecystectomyen_US
dc.title.alternativeLaparoskopik cerrahi geçirecek erişkin olgularda i?ntraabdominal i?nsüflasyon basincinin karaci?er fonksiyonlarina etkisien_US
dc.typeArticleen_US

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